TISSUE MATRICES INCORPORATING MULTIPLE TISSUE TYPES
The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.
1 . A method of treatment comprising;
selecting a tissue product, wherein the tissue product comprises;
a first component comprising a sheet of acellular dermal tissue matrix; and
a second component comprising a porous acellular tissue matrix sponge covering at least a portion of the intact acellular tissue matrix; and
implanting the tissue product into a patient.
2 . The method of claim 1 , wherein implanting the tissue product comprises implanting the tissue product subcutaneously.
3 . The method of claim 1 , wherein implanting the tissue product comprises implanting the tissue product subpectorally.
4 . The method of claim 1 , wherein implanting the tissue product comprises placing the tissue product over a breast implant or tissue expander.
5 . The method of claim 1 , further comprising shaping the second component of the tissue product.
6 . The method of claim 5 , wherein shaping includes one of cutting, slicing, grinding, or scraping.
7 . The method of claim 1 , wherein implanting the tissue product comprises affixing the tissue product to the chest wall, muscle, or skin of the patient.
8 . The method of claim 1 , further comprising:
implanting an implant or tissue expander into an anatomic site; and
affixing the tissue product to the breast implant or tissue expander.
9 . A breast implant device comprising;
a tissue product, wherein the tissue product comprises:
a first component comprising a sheet of acellular dermal tissue matrix; and
a second component comprising a sheet of a second acellular tissue matrix derived from a tissue type different than that of the first component; and
a breast implant, wherein the breast implant comprises;
a flexible outer wall; and
an inner volume containing a liquid or gel.
10 . The tissue product of claim 9 , wherein the second component comprises a porous acellular tissue matrix sponge covering at least a portion of the first component.
11 . The tissue product of claim 9 , further comprising a third component contained between the first component and the second component.
12 . The tissue product of claim 11 , wherein the first component and second component completely enclose the third component.
13 . The tissue product of claim 11 , wherein the first component and second component are sheets of tissue matrix and the third component is a porous acellular tissue matrix sponge.
14 . The tissue product of claim 9 , wherein the porous acellular tissue matrix sponge covers a top side and a bottom side of the sheet of acellular dermal matrix.
15 . The tissue product of claim 9 , wherein at least a portion of a surface of the sheet of acellular tissue matrix is textured, roughened, or indented.
16 . The tissue product of claim 9 , further comprising at least one additional acellular tissue matrix sheet, comprising a skeletal muscle matrix.
17 . The tissue product of claim 9 , wherein the breast implant is provided in volumes of about 100 cc to 2000 cc.
18 . The tissue product of claim 9 , wherein the breast implant comprises a saline-filled implant.
19 . The tissue product of claim 9 , wherein the breast implant comprises a silicone-filled implant.
20 . The tissue product of claim 9 , wherein the breast implant comprises a tissue expander.