Ingestible device for delivery of a dispensable substance
Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.
1. An ingestible device, comprising:
a storage reservoir in a housing;
a dispensable substance in the storage reservoir;
a nozzle in the housing;
a piston slidable within the housing;
the storage reservoir formed between the piston and inner walls of the housing;
and
a pre-pressurized compressed gas chamber in the housing;
an occluder having a first state configured to prevent the dispensable substance from exiting the ingestible device via the nozzle, and the occluder having a second state configured to allow compressed gas from the pre-pressurized compressed gas chamber to drive the piston to provide a jet of the dispensable substance out of the nozzle for systemic delivery of the dispensable substance.
2. The ingestible device of claim 1 wherein the compressed gas generates a pressure of 100-360 psi.
3. The ingestible device of claim 2 wherein the compressed gas generates a pressure of about 300 psi.
4. The ingestible device of claim 1 wherein the nozzle extends radially outward through a sidewall of the housing in a direction perpendicular to a longitudinal axis of the ingestible device.
5. The ingestible device of claim 1 comprising a plurality of nozzles.
6. The ingestible device of claim 5 comprising two, three, four, five or six nozzles equally spaced apart to balance reaction forces.
7. The ingestible device of claim 1 wherein the storage reservoir comprises a capillary structure.
8. The ingestible device of claim 1 wherein the occluder comprises a burst disc.
9. The ingestible device of claim 1 further comprising:
a plurality of nozzles in the housing, each nozzle extending radially outward through the housing in a direction perpendicular to a longitudinal axis of the ingestible device.
10. The ingestible device of claim 9 wherein the occluder includes an occlusion component which weakens or dissolves after the ingestible device is ingested.