Delivery of hydrophobic active agent particles
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
1. A drug delivery coating comprising
a base polymeric layer, the base polymeric layer comprising a hydrophilic surface and a photo-crosslinker comprising at least two aryl ketone functionalities;
a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising
a particulate hydrophobic therapeutic agent; and
a cationic agent, the cationic agent comprising polyethyleneimine (PEI);
wherein a ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 90/10.
2. The drug delivery coating of claim 1 , wherein the ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 95/5.
3. The drug delivery coating of claim 1 , wherein the ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 98/2.
4. The drug delivery coating of claim 1 , wherein the ratio (wt./wt.) of particulate hydrophobic therapeutic agent to the cationic agent is about 99.9/0.1 to 99/1.
5. The drug delivery coating of claim 1 , the cationic agent comprising a polyethyleneimine (PEI) homopolymer or copolymer.
6. The drug delivery coating of claim 5 , the copolymer comprising a PEG block.
7. The drug delivery coating of claim 5 , the copolymer selected from the group consisting of PEG-PEI and PLGA-PEI.
8. The drug delivery coating of claim 1 , wherein the photo-crosslinker is chosen from ethylenebis(4-benzoylbenzyldimethylammonium) dibromide and bis(4-benzoyl)phosphate sodium salt.
9. The drug delivery coating of claim 1 , wherein the base polymeric layer comprises a hydrophilic polymer having pendent photoreactive groups.
10. The drug delivery coating of claim 9 , the hydrophilic polymer having pendent photoreactive groups comprising a photo-polyacrylamide.
11. The drug delivery coating of claim 10 , wherein the photo-polyacrylamide is chosen from poly(N-3-aminopropyl)methacrylamide-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide; poly(acrylamide-co-N-(3-(4-benzoylbenzamido)propyl)methacylamide), poly(acrylamide-co-maleic-6-aminocaproic acid-N-oxysuccinimide-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide) and poly(acrylamide-co-(3-(4-benzoylbenzamido)propyl)methacrylamide)-co-glycidylmethacrylate.
12. The drug delivery coating of claim 10 , wherein the photo-polyacrylamide is poly(N-3-aminopropyl)methacrylamide-co-N-(3-(4-benzoylbenzamido)propyl) methacrylamide.
13. The drug delivery coating of claim 10 , wherein the photo-polyacrylamide is poly(N-3-aminopropyl)methacrylamide-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide and the photo crosslinker is ethylenebis(4-benzoylbenzyldimethylammonium) dibromide.