IP Library › Granted Patent US 11,299,517
Granted Patent B2
US 11,299,517 · App. 16/848,880 · Granted Apr 12, 2022

Recombinant vaccine against Marek's disease and Newcastle disease

Inventors: Qingzhong Yu (Athens, GA); Stephen J. Spatz (Bogart, GA); John R. Dunn (East Lansing, GA)
Assignee: The United States of America, as represented by The Secretary of Agriculture
C07K14/125C07K14/055C12N7/00A61K38/00
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Quick Facts
Patent No.
US 11,299,517
App. No.
16/848,880
Granted
Apr 12, 2022
Kind
B2
Abstract

Provided herein are immunogenic compositions containing recombinant viruses capable of inducing protection in poultry against both Marek's disease virus (MDV) and Newcastle disease virus (NDV). Such viruses incorporate nucleic acids for expressing at least one MDV antigen, such as glycoprotein B, and antigenic portions thereof, in a recombinant NDV genome.

Claims (14)

1. A composition comprising a nucleic acid at least 95% identical to SEQ ID NO:3.

2. The composition of claim 1 , comprising a nucleic acid at least 99% identical to SEQ ID NO:3.

3. A vector comprising the nucleic acid of claim 1 .

4. The vector of claim 3 , wherein the vector comprises a nucleic acid encoding a synthetic polypeptide having an amino acid sequence at least 95% identical to SEQ ID NO:2.

5. The vector of claim 3 , wherein the vector comprises a nucleic acid encoding a synthetic polypeptide comprising SEQ ID NO:2.

6. The vector of claim 3 , wherein the recombinant NDV comprises a nucleic acid having at least 99% identity to SEQ ID NO:3.

7. The vector of claim 3 , wherein the recombinant NDV comprises SEQ ID NO: 3.

8. A method of eliciting an immune response against Marek's disease virus (MDV) and Newcastle disease virus (NDV) in a subject, comprising administering to the subject a composition comprising a recombinant NDV, wherein the recombinant NDV comprises a nucleic acid having at least 95% identity to SEQ ID NO: 3.

9. The method of claim 8 , wherein the recombinant NDV comprises a nucleic acid encoding a synthetic polypeptide having an amino acid sequence at least 95% identical to SEQ ID NO: 2.

10. The method of claim 8 , wherein the recombinant NDV comprises a nucleic acid encoding a synthetic polypeptide comprising SEQ ID NO: 2.

11. The method of claim 8 , wherein the recombinant NDV comprises a nucleic acid having at least 99% identity to SEQ ID NO: 3.

12. The method of claim 8 , wherein the recombinant NDV comprises SEQ ID NO: 3.

13. The method of claim 8 , wherein the subject is poultry.

14. The method of claim 9 , wherein the subject is a chicken.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2020
From: YU, QINGZHONG; SPATZ, STEPHEN J; DUNN, JOHN R
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
Reel/Frame 053153/0545 →
Continuity (1)
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