IP Library Granted Patent US 11,504,511
Granted Patent B2
US 11,504,511 · App. 16/849,391 · Granted Nov 22, 2022

Ingestible device with pharmaceutical product

Inventors: Hooman Hafezi (Redwood City, CA); Raymond Schmidt (San Francisco, CA)
Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
A61M31/002A61B5/14503A61B5/4833A61J3/071A61K9/0097A61K9/4808A61M2205/0238A61M2205/33A61M2205/50A61M2205/82A61M2207/00Y10T29/49826
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Quick Facts
Patent No.
US 11,504,511
App. No.
16/849,391
Granted
Nov 22, 2022
Kind
B2
Abstract

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

Claims (23)

1. An ingestible device, comprising:

electronic components;

a skirt material surrounding the electronic components in one planar dimension, the skirt material comprising a plurality of holes;

a first protective sheet over a first side of the electronic components and the skirt material; and

a second protective sheet over a second side of the electronic components and the skirt material, the second side positioned opposite the first side;

wherein the first protective sheet and the second protective sheet are secured to one another via heat or pressure through the plurality of holes of the skirt material;

wherein the first protective sheet and the second protective sheet are configured to disintegrate when immersed in conductive fluid; and

wherein the ingestible device is configured to encode information in a current signature using the conductive fluid as a transmissible medium.

2. The ingestible device of claim 1 , further configured to be positioned within a capsule having an upper end and a lower end, wherein the upper and lower ends are brought together to form a housing that defines a cavity and wherein the cavity is filled with a drug, the capsule configured to disintegrate when in contact with a surrounding fluid.

3. The ingestible device of claim 2 , wherein the first protective sheet and the second protective sheet are configured to begin to disintegrate after the capsule has disintegrated and has exposed the content of the capsule to the surrounding fluids.

4. The ingestible device of claim 1 , further comprising dissolvable components that are surrounded by the first protective sheet and the second protective sheet.

5. The ingestible device of claim 2 , wherein the first protective sheet and the second protective sheet together configured to prevent at least one of the capsule or the drug from interacting with the electronic components of the ingestible device.

6. The ingestible device of claim 2 , wherein the protective layer is configured to delay exposure of the electronic components to the surrounding fluid.

7. The ingestible device of claim 6 , wherein the delayed exposure delays activation of the ingestible device.

8. The ingestible device of claim 1 , wherein the first protective sheet comprises two different materials.

9. The ingestible device of claim 1 , wherein at least one of the first protective sheet and the second protective sheet comprises at least one of polyethylene oxide, hydroxypropyl cellulose, and triethyl citrate.

10. The ingestible device of claim 1 , wherein the first protective sheet and the second protective sheet provides a moisture barrier over the electronic components.

11. The ingestible device of claim 1 , wherein at least one of the first protective sheet and the second protective sheet comprises a plasticizer and a stabilizer.

12. The ingestible device of claim 1 , wherein the skirt comprises a plurality of legs protruding outwardly from the electronic components.

13. The ingestible device of claim 12 , wherein the plurality of legs are configured to hold the ingestible device in place within a housing by applying friction to one or more inner walls of the housing.

14. The ingestible device of claim 1 , wherein the first protective sheet and the second protective sheet are laminated over the electronic components and the skirt material.

15. The ingestible device of claim 1 , wherein the first protective sheet and the second protective sheet are dry compressed over the electronic components and the skirt material.

16. The ingestible device of claim 1 , wherein the first protective sheet and the second protective sheet are oversized compared to a size of the skirt material.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2021
From: OTSUKA AMERICA PHARMACEUTICAL, INC.
To: OTSUKA PHARMACEUTICAL CO., LTD.
Reel/Frame 056240/0497 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2021
From: PROTEUS DIGITAL HEALTH, INC.
To: OTSUKA AMERICA PHARMACEUTICAL, INC.
Reel/Frame 055704/0609 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2020
From: HAFEZI, HOOMAN; SCHMIDT, RAY
To: PROTEUS DIGITAL HEALTH, INC.
Reel/Frame 052405/0860 →
Continuity (5)
Continuation 15491409 · Apr 19, 2017
Division 14829229 · Aug 18, 2015
Division 13521993
Provisional Application 61416150 · Nov 22, 2010
Related Publication 20210060319A1 · Mar 4, 2021