IP Library Granted Patent US 11,040,066
Granted Patent B2
US 11,040,066 · App. 16/850,136 · Granted Jun 22, 2021

Topical composition for use in the treatment of burns

Inventor: Mark Lait (Hertford, GB)
Assignee: Safeguard Medical Holdco, LLC
A61K35/08A61K9/0014A61K9/7007A61K47/10A61K47/34A61P17/02
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Quick Facts
Patent No.
US 11,040,066
App. No.
16/850,136
Granted
Jun 22, 2021
Kind
B2
Abstract

The present disclosure relates to topical compositions comprising water, solvent, thickener, preservative and conditioning agent wherein the composition has a viscosity approximately in the range 200-6000 cP at 25° C. following exposure to gamma radiation, to use of the composition in a dressing and the use of compositions and dressings in treatment or prophylaxis of burns.

Claims (27)

1. A topical composition consisting of:

approximately 89.85% w/w purified water;

approximately 8% w/w propanediol;

approximately 0.8% w/w sodium acryloyldimethyltaurate/VP crosspolymer;

approximately 1% w/w combination of phenoxyethanol, caprylyl glycol and chlorphenesin;

approximately 0.25% w/w mineral complex; and

approximately 0.1% w/w polyaminopropyl biguanide (PHMB) of the composition;

wherein the composition has a viscosity approximately in the range of 200-6000 cP at 25° C. following exposure to gamma radiation.

2. A topical composition according to claim 1 wherein the mineral complex is sea water extract.

3. A topical composition according to claim 1 wherein the mineral complex comprises magnesium, potassium, sodium, boron, calcium and optionally one or more from the group consisting: copper, nickel, silicon, zinc, aluminium, arsenic, barium, cadmium, cobalt, chromium, iron, mercury, manganese, lead, antimony, selenium, tin, strontium, titanium and vanadium.

4. A topical composition according to claim 1 wherein the composition has a specific gravity of approximately 1.000±0.05 at 25° C.

5. A topical composition according to claim 1 wherein the composition has a pH approximately in the range 4.0-6.5 at 25° C.

6. A burn dressing comprising a topical composition according to claim 1 and a dressing material.

7. A burn dressing according to claim 6 wherein the dressing material comprises thermal bonded, non-woven material.

8. A burn dressing according to claim 6 wherein the dressing material comprises super absorbent material.

9. A burn dressing according to claim 6 wherein the dressing material comprises polypropylene fibre and rayon fibre.

10. A burn dressing according to claim 8 wherein the dressing material is approximately 20% super absorbent fibre.

11. A burn dressing according to claim 6 wherein the dressing material has one of more of the properties selected from the group consisting of: a weight of approximately 50 gsm, a thickness of approximately 0.63 mm, a tensile strength of approximately 4.2 N or 24.3 N, an absorbent capacity of approximately 22.7 g/g and an absorbent volume of approximately >1150 gsm.

12. A method of sterilising a topical composition according to claim 1 comprising applying gamma radiation of approximately 25.0 to 44.5 kGy to the composition.

13. A method of sterilising according to claim 12 wherein the gamma radiation is cobalt 60 irradiation.

14. A composition according to claim 1 which has been sterilised using the method of claim 12 .

15. A kit of parts comprising a composition according to claim 1 and a dressing material.

16. A method of prophylaxis or treatment of a burn comprising the step of applying a topical composition according to claim 1 to skin in need thereof.

17. A method of prophylaxis or treatment according to claim 16 wherein the composition is applied for approximately 24 hours.

18. A burn dressing according to claim 6 which has been sterilised using the method of claim 12 .

19. A method of prophylaxis or treatment of a burn comprising the step of applying a burn dressing according to claim 6 to skin in need thereof.

20. A method of prophylaxis or treatment according to claim 19 wherein the dressing is applied for approximately 24 hours.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Jun 2, 2022
From: HSBC BANK USA, NATIONAL ASSOCIATION
To: SAFEGUARD MEDICAL HOLDCO LLC
Reel/Frame 060079/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA BY REMOVING THE NAME PHILIPPA BROWN, WHICH WAS INADVERTERNTLY LISTED AND PREVIOUSLY RECORDED AT REEL: 052558 FRAME: 0619. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 17, 2021
From: LAIT, MARK
To: WATER-JEL EUROPE LLC
Reel/Frame 056615/0483 →
SECURITY INTEREST Recorded May 3, 2021
From: SAFEGUARD MEDICAL HOLDCO, LLC
To: HSBC BANK USA
Reel/Frame 056113/0380 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2020
From: WATER-JEL EUROPE, LLP
To: SAFEGUARD MEDICAL HOLDCO, LLC
Reel/Frame 053682/0460 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2020
From: LAIT, MARK; BROWN, PHILIPPA
To: WATER-JEL EUROPE LLP
Reel/Frame 052558/0619 →
Priority Claims (2)
GB 1717224 · Oct 20, 2017 · national
GB 1813442 · Aug 17, 2018 · national
Continuity (2)
Continuation PCTIB2018058089 · Oct 18, 2018
Related Publication 20200237816A1 · Jul 30, 2020