IP Library Granted Patent US 11,517,746
Granted Patent B2
US 11,517,746 · App. 16/850,926 · Granted Dec 6, 2022

Obstructive sleep apnea treatment devices, systems and methods

Inventors: Stephen L. Bolea (Watertown, MN); Thomas B. Hoegh (Edina, MN); Bruce J. Persson (Dressar, WI); Robert E. Atkinson (White Bear Lake, MN); Scott T. Mazar (Woodbury, MN)
Assignee: LivaNova USA, Inc.
A61N1/0556A61N1/0558A61N1/3601A61N1/3606A61N1/37229A61B5/0809A61B5/4818A61B5/7239
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Quick Facts
Patent No.
US 11,517,746
App. No.
16/850,926
Granted
Dec 6, 2022
Kind
B2
Abstract

A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea. The stimulation system includes an implantable receiver coil configured to be implanted under a mandible of the patient; a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient; an external pulse generator configured to generate the stimulation signal; and an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient.

Claims (43)

1. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:

an implantable receiver coil configured to be implanted under a mandible of the patient;

a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;

an external pulse generator configured to generate the stimulation signal; and

an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient,

wherein the implantable receiver coil and the external transmitter coil each comprise air core wire coils.

2. The stimulation system of claim 1 , further comprising:

a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,

wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters.

3. The stimulation system of claim 1 , wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, a matched numbers of wire turns, or matched wire gauges.

4. The stimulation system of claim 1 , wherein the implantable receiver coil and the external transmitter coil are disposed in a co-axial and parallel arrangement.

5. The stimulation system of claim 1 , wherein the stimulation signal has an operating carrier frequency of 13.56 MHz.

6. The stimulation system of claim 1 , wherein the stimulation signal has an operating carrier frequency of 1.8 MHz.

7. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:

an implantable receiver coil configured to be implanted under a mandible of the patient;

a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;

an external pulse generator configured to generate the stimulation signal; and

an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil configured to be adhesively attached to the patient adjacent the implantable receiver coil under the mandible of the patient,

wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, matched numbers of wire turns, or matched wire gauges.

8. The stimulation system of claim 7 , further comprising:

a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,

wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters.

9. The stimulation system of claim 8 , wherein the sensor is a position sensor and the external pulse generator is configured to adjust the stimulation signal based on a body position of the patient.

10. The stimulation system of claim 9 , wherein the external pulse generator is configured to automatically shut off stimulation when patient sits up or stands up.

11. The stimulation system of claim 7 , wherein the implantable receiver coil and the external transmitter coil are disposed in a co-axial and parallel arrangement.

12. The stimulation system of claim 7 , wherein the stimulation signal has an operating carrier frequency of at least one of 1.8 MHz or 13.56 MHz.

13. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:

an implantable receiver coil configured to be implanted in a subcutaneous pocket under a mandible of the patient;

a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;

an external pulse generator configured to generate the stimulation signal;

an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient; and

a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,

wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters, and

wherein the sensor is a position sensor and the external pulse generator is configured to adjust the stimulation signal based on a body position of the patient.

14. The stimulation system of claim 13 , wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, a matched numbers of wire turns, or matched wire gauges.

15. The stimulation system of claim 13 , wherein the sensor comprises at least one of:

an impedance sensor;

an electromyographical measurement sensor;

a microphone configured to be arranged proximate the patient's face;

a combination of a flow sensor and a pressure sensor collectively configured to measure flow; or

a temperature sensor configured to detect a difference between cool inspired air versus warm expired air.

16. The stimulation system of claim 13 , wherein the nerve electrode includes a plurality of electrode contacts that are longitudinally arranged along the hypoglossal nerve.

17. The stimulation system of claim 13 , wherein the stimulation signal has an operating carrier frequency of at least one of 1.8 MHz or 13.56 MHz.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: LIVANOVA USA, INC.
Reel/Frame 057552/0378 →
SECURITY INTEREST Recorded Aug 16, 2021
From: LIVANOVA USA, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0001 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: LIVANOVA USA, INC.
Reel/Frame 057189/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: LIVANOVA USA, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0784 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: LIVANOVA USA, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 053673/0675 →
Continuity (6)
Continuation 15665319 · Jul 31, 2017
Continuation 12835984 · Jul 14, 2010
Continuation 11907532 · Oct 12, 2007
Provisional Application 60918257 · Mar 14, 2007
Provisional Application 60851386 · Oct 13, 2006
Related Publication 20200316373A1 · Oct 8, 2020