METHODS OF TREATING HYPERTRIGLYCERIDEMIA
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
1 .- 10 . (canceled)
11 . A method of reducing LDL-P in a subject in need thereof, comprising:
determining a baseline LDL-P level associated with the subject; and
administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of ethyl eicosapentaenoate per day.
12 . The method of claim 11 , further comprising, measuring a baseline lipid profile in the subject prior to administering the pharmaceutical composition to the subject.
13 . The method of claim 11 , wherein after administration of the pharmaceutical composition, the subject experiences a reduction in LDL-P of at least about 5% compared to baseline.
14 . The method of claim 13 , wherein the reduction in LDL-P of at least about 5 % compared to baseline is actual % change or median % change.
15 . The method of claim 11 , wherein the subject is administered 2 g to about 4 g of ethyl eicosapentaenoate per day.
16 . The method of claim 11 , wherein the pharmaceutical composition is administered to the subject 1 to 4 times per day.
17 . The method of claim 11 , wherein the ethyl eicosapentaenoate comprises at least about 90%, by weight, of all fatty acids in the pharmaceutical composition.
18 . The method of claim 17 , wherein docosahexaenoic acid and its derivatives comprise no more than about 10%, by weight, of all fatty acids in the pharmaceutical composition.
19 . The method of claim 18 , wherein the pharmaceutical composition is present in a capsule.
20 . The method of claim 16 , wherein the subject is not on concomitant lipid-altering therapy.
21 . The method of claim 20 , wherein the subject is diabetic.
22 . The method of claim 19 , wherein the pharmaceutical composition is packaged in blister packages of about 1 to less than about 20 capsules per sheet.