Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.
1. A compound of Formula IV, or a pharmaceutically acceptable salt thereof:
wherein:
aa 1 is valine, lysine, serine, alanine, isoleucine, histidine, or O-benzylserine;
aa 2 is valine, lysine, serine, alanine, isoleucine, histidine, O-benzylserine, or is absent; and
wherein one or more hydrogen atoms are replaced by deuterium.
2. The compound of claim 1 , wherein aa 1 is valine and aa 2 is absent.
3. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier.
4. A compound having the structural formula:
wherein one or more hydrogen atoms are replaced by deuterium.
5. A pharmaceutical composition comprising the compound of claim 4 and a pharmaceutically acceptable carrier.
6. The pharmaceutical composition of claim 5 in a form suitable for oral administration.
7. The pharmaceutical composition of claim 6 , which is in the form of a hard shell gelatin capsule, soft shell gelatin capsule, cachet, pill, tablet, lozenge, powder, granule, pellet, dragee, each of which is optionally enteric coated; a solution; an aqueous liquid suspension; a non-aqueous liquid suspension; an oil-in-water liquid emulsion; a water-in-oil liquid emulsion; an elixir; a syrup; or a pastille.
8. The pharmaceutical composition of claim 7 , which is in the form of a hard shell gelatin capsule, soft shell gelatin capsule, or an enterically coated capsule.