Granted Patent
B1
US 10,836,729 · App. 16/865,479 · Granted Nov 17, 2020
Metabolically stable 5-HMF derivatives for the treatment of hypoxia
Inventors:
Abdelsattar Mansour Ebeid Omar (Jeddah, SA); Moustafa El-Sayed El-Araby (Jeddah, SA); Martin K. Safo (Richmond, VA)
Assignee:
King Abdulaziz University
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Abstract
5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
Claims (8)
1. A compound, or pharmaceutically acceptable salt or solvate thereof, wherein said compound is
2. A pharmaceutical composition comprising:
a liquid or solid carrier; and
the compound, or pharmaceutically acceptable salt or solvate thereof, of claim 1 .
3. A compound, or pharmaceutically acceptable salt or solvate thereof, wherein said compound is
4. A pharmaceutical composition comprising:
a liquid or solid carrier; and
the compound, or pharmaceutically acceptable salt or solvate thereof, of claim 3 .
Assignments (3)
CONFIRMATORY LICENSE
Recorded Oct 2, 2023
From: VIRGINIA COMMENWEALTH UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065091/0375 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 4, 2020
From: OMAR, ABDELSATTAR MANSOUR EBEID; EL-ARABY, MOUSTAFA EL-SAYED
To: KING ABDULAZIZ UNIVERSITY
Reel/Frame 052558/0031 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 4, 2020
From: SAFO, MARTIN K.
To: VIRGINIA COMMONWEALTH UNIVERSITY
Reel/Frame 052558/0067 →