IP Library Granted Patent US 11,620,789
Granted Patent B2
US 11,620,789 · App. 16/866,417 · Granted Apr 4, 2023

Methods, systems, and apparatuses for managing transducer array placement

Inventors: Hadas Sara Hershkovich (Haifa, IL); Zeev Bomzon (Haifa, IL); Gil Zigelman (Haifa, IL); Shira Luk-Zilberman (Haifa, IL); Ori Kook (Haifa, IL); Oren Ben Zion Bakalo (Haifa, IL)
Assignee: Novocure GmbH
G06T17/00A61N1/40G06T2210/41
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Quick Facts
Patent No.
US 11,620,789
App. No.
16/866,417
Granted
Apr 4, 2023
Kind
B2
Abstract

Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.

Claims (50)

1. A method comprising:

generating a three-dimensional (3D) model of a portion of a subject's body;

determining, based on the 3D model and a plurality of simulated electrical field distributions, a plurality of transducer array layout maps, each transducer array layout map comprising:

a first pair of positions for placement of a first transducer array and a second transducer array; and

a second pair of positions for placement of a third transducer array and a fourth transducer array;

determining, from the plurality of transducer array layout maps, one or more sets of transducer array layout maps, wherein each set of transducer array layout maps represents at least two transducer array layout maps that satisfy a criterion, wherein the first and second pairs of positions of any one transducer array layout map in the set are not at the same positions on the 3D model as the first and second pairs of positions of any other transducer array layout map in the set; and

causing display of the one or more sets of transducer array layout maps.

2. The method of claim 1 , wherein the criterion comprises at least one of a magnitude of a simulated electric field distribution of the plurality of simulated electrical field distributions within a region-of-interest (ROI) associated with the 3D model, a power density associated with a simulated electric field distribution of the plurality of simulated electrical field distributions within the ROI, or an estimate of skin toxicity associated with the portion of the subject's body.

3. The method of claim 1 , further comprising receiving a selection of a set of transducer array layout maps of the one or more sets of transducer array layout maps.

4. The method of claim 3 , further comprising generating, based on the selected set of transducer array layout maps, composite data.

5. The method of claim 4 , wherein the composite data comprises information associated with the selected set of transducer array layout maps and simulated electrical field distributions of the plurality of simulated electrical field distributions associated with the selected set of transducer array layout maps.

6. The method of claim 4 , further comprising sending, to a user device, the composite data.

7. The method of claim 1 , wherein generating the 3D model comprises:

causing one or more user devices to display a plurality of images of the portion of the subject's body;

receiving, based on a region-of-interest (ROI), a selection of one or more images of the plurality of images; and

generating, based on the one or more images, the 3D model.

8. The method of claim 7 , further comprising receiving, from a first user device of the one or more user devices, information associated with the ROI, and wherein receiving the selection of the one or more images comprises receiving the selection of the one or more images from a second user device of the one or more user devices.

9. The method of claim 1 , wherein determining the plurality of transducer array layout maps comprises:

determining, based on the 3D model, a plurality of pairs of positions for transducer array placement;

determining, for each pair of positions of the plurality of pairs positions, a simulated electrical field distribution of the plurality of simulated electrical field distributions; and

determining, based on the plurality of simulated electrical field distributions, the plurality of transducer array layout maps.

10. The method of claim 9 , wherein determining the simulated electrical field distribution for each pair of positions of the plurality of pairs positions comprises:

simulating, at a first position of the pair of positions, a first electrical field generated by a first transducer array;

simulating, at a second position of the pair of positions, a second electrical field generated by a second transducer array, wherein the second position is opposite the first position; and

determining, based on the first electrical field and the second electrical field, the simulated electrical field distribution.

11. A method comprising:

generating a three-dimensional (3D) model of a portion of a subject's body;

determining, based on the 3D model and a plurality of simulated electrical field distributions, a plurality of transducer array layout maps, each transducer array layout map comprising:

a first pair of positions for placement of a first transducer array and a second transducer array; and

a second pair of positions for placement of a third transducer array and a fourth transducer array;

receiving a selection of a first transducer array layout map of the plurality of transducer array layout maps, wherein the first transducer array layout map satisfies a criterion;

determining, from the plurality of transducer array layout maps, one or more associated transducer array layout maps, wherein the first and second pairs of positions of each associated transducer array layout map are not at the same positions on the 3D model as the first and second pairs of positions of the first transducer array layout map, wherein each associated transducer array layout map satisfies the criterion;

receiving a selection of a second transducer array layout map from the one or more associated transducer array layout maps; and

causing display of the first transducer array layout map and the second transducer array layout map.

12. The method of claim 11 , wherein the criterion comprises at least one of: a magnitude of a simulated electric field distribution of the plurality of simulated electrical field distributions within a region-of-interest (ROI) associated with the 3D model, a power density associated with a simulated electric field distribution of the plurality of simulated electrical field distributions within the ROI, or an estimate of skin toxicity associated with the portion of the subject's body.

13. The method of claim 11 , further comprising generating, based on the first transducer array layout map and the second transducer array layout map, composite data.

14. The method of claim 13 , wherein the composite data comprises information associated with the first transducer array layout map and the second transducer array layout map and simulated electrical field distributions of the plurality of simulated electrical field distributions associated with the first transducer array layout map and the second transducer array layout map.

15. The method of claim 11 , wherein generating the 3D model comprises:

causing one or more user devices to display a plurality of images of the portion of the subject's body;

receiving, based on a region-of-interest (ROI), a selection of one or more images of the plurality of images; and

generating, based on the one or more images, the 3D model.

16. The method of claim 15 , further comprising receiving, from a first user device of the one or more user devices, information associated with the ROI, and wherein receiving the selection of the one or more images comprises receiving the selection of the one or more images from a second user device of the one or more user devices.

17. The method of claim 11 , wherein determining the plurality of transducer array layout maps comprises:

determining, based on the 3D model, a plurality of pairs of positions for transducer array placement;

determining, for each pair of positions of the plurality of pairs positions, a simulated electrical field distribution of the plurality of simulated electrical field distributions; and

determining, based on the plurality of simulated electrical field distributions, the plurality of transducer array layout maps.

18. The method of claim 17 , wherein determining the simulated electrical field distribution for each pair of positions of the plurality of pairs positions comprises:

simulating, at a first position of the pair of positions, a first electrical field generated by a first transducer array;

simulating, at a second position of the pair of positions, a second electrical field generated by a second transducer array, wherein the second position is opposite the first position; and

determining, based on the first electrical field and the second electrical field, the simulated electrical field distribution.

Assignments (6)
PATENT SECURITY AGREEMENT Recorded May 4, 2024
From: NOVOCURE GMBH (SWITZERLAND)
To: BIOPHARMA CREDIT PLC
Reel/Frame 067315/0399 →
RELEASE OF SECURITY INTEREST Recorded Apr 24, 2024
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: NOVOCURE GMBH
Reel/Frame 067211/0839 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECT THE 3RD INVENTORS NAME PREVIOUSLY RECORDED ON REEL 057396 FRAME 0573. ASSIGNOR(S) HEREBY CONFIRMS THE GIL ZIGELMAN. Recorded Nov 22, 2021
From: HERSHKOVICH, HADAS SARA; BOMZON, ZEEV; ZIGELMAN, GIL; LUK-ZILBERMAN, SHIRA; KOOK, ORI; BAKALO, OREN BEN ZION
To: NOVOCURE GMBH
Reel/Frame 059190/0639 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECTING 6TH INVENTORS NAME ON ASSIGNMENT DOCUMENT SHOULD BE OREN BEN ZION BAKALO PREVIOUSLY RECORDED AT REEL: 056568 FRAME: 0233. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 2, 2021
From: HERSHKOVICH, HADAS SARA; BOMZON, ZEEV; ZIGLEMAN, GIL; LUK-ZILBERMAN, SHIRA; KOOK, ORI; BAKALO, OREN BEN ZION
To: NOVOCURE GMBH
Reel/Frame 057396/0573 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 16, 2021
From: HERSHKOVICH, HADAS SARA; BOMZON, ZEEV; ZIGLEMAN, GIL; LUK-ZILBERMAN, SHIRA; KOOK, ORI; BAKALO, OREN BEN ZION
To: NOVOCURE GMBH
Reel/Frame 056568/0233 →
SECURITY INTEREST Recorded Nov 6, 2020
From: NOVOCURE GMBH
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 054344/0510 →
Continuity (2)
Provisional Application 62842674 · May 3, 2019
Related Publication 20200372705A1 · Nov 26, 2020
Cited By (2)
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