Aqueous oral care fluoride treatment compositions, and methods
An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.
1. A colloid dispersion composition for use in oral care, the colloid dispersion comprising:
a fluoride-releasing composition effective to release fluoride to a tooth surface;
a crosslinked polyacid polymer;
a water-soluble multivalent cation salt;
a thickener selected from non-acid cellulose derivatives, inorganic fillers, alkylene oxide polymers, non-acid modified starches, and a combination thereof; and
a pharmaceutically acceptable buffer;
water present in an amount of at least 60 wt % based on the total weight of the colloid dispersion composition,
wherein the colloid dispersion composition is characterized by a viscosity of 0.5 to 500 Pascal seconds at a shear rate of 1.0/second.
2. The colloid dispersion composition of claim 1 , the fluoride-releasing composition comprising sodium fluoride, sodium monofluorophosphate, stannous fluoride, calcium fluoride, strontium fluoride, zinc fluoride, zinc potassium fluoride, ammonium fluoride, potassium fluoride, magnesium fluoride, or a combination thereof.
3. The colloid dispersion composition of claim 2 , wherein the sodium fluoride, sodium monofluorophosphate, stannous fluoride, calcium fluoride, strontium fluoride, zinc fluoride, zinc potassium fluoride, ammonium fluoride, potassium fluoride, magnesium fluoride, or a combination thereof is present in an amount of at least 1.0 wt % with respect to the weight of the composition.
4. The colloid dispersion composition of claim 1 , the crosslinked polyacid polymer derived from one or more of the following monomers: acrylic acid, maleic acid, maleic anhydride, itaconic acid, vinyl ether, an C 10-30 alkyl acrylate, and a saccharide.
5. The colloid dispersion composition of claim 1 , the crosslinked polyacid polymer comprising a polyacid polymer crosslinked with a polyalkenyl alcohol or divinyl glycol.
6. The colloid dispersion composition of claim 1 , the crosslinked polyacid polymer comprising a polyacid polymer crosslinked with allyl sucrose, allyl pentaerythritol, glycerol, diglycerol, polyglycerol, polyalkenyl alcohol, divinyl glycol, or a combination thereof.
7. The colloid dispersion composition of claim 1 , the crosslinked polyacid polymer comprising polyacrylic acid crosslinked with allyl pentaerythritol.
8. The colloid dispersion composition of claim 1 , wherein the multivalent cation salt comprises calcium, magnesium, barium, manganese, iron, zinc, aluminum, copper, or a combination thereof.
9. The colloid dispersion composition of claim 1 , wherein the multivalent cation salt is selected from calcium chloride, calcium nitrate, calcium gluconate, calcium lactate gluconate, calcium acetate, a hydrate thereof, and a combination thereof.
10. The colloid dispersion composition of claim 1 , wherein the multivalent cation salt is selected from aluminum chloride, aluminum sulfate, aluminum nitrate, potassium aluminum sulfate, a hydrate thereof, and a combination thereof.
11. The colloid dispersion composition of claim 1 , wherein the thickener is a non-acid cellulose derivative.
12. The colloid dispersion composition of claim 1 , the pharmaceutically acceptable buffer selected from sodium acetate, sodium carbonate, sodium citrate, disodium hydrogen phosphate, triethanolamine, or a combination thereof.
13. The colloid dispersion composition of claim 1 , characterized by a pH of 6 to 8.
14. The colloid dispersion composition of claim 1 , further comprising one or more remineralizing agent.
15. A method of treating a tooth surface with fluoride, the method comprising:
contacting the tooth surface with a colloid dispersion composition of claim 1 ; and
allowing the colloid dispersion composition to remain in contact with the tooth surface for a period effective to release fluoride from the colloid dispersion composition to the tooth surface.
16. The method of claim 15 , wherein the contacting comprises placing a dental tray on the tooth surface, wherein the colloid dispersion composition is dispensed in the dental tray.
17. The method of claim 15 , wherein the colloid dispersion releases fluoride at a rate of up to 93% of fluoride in 1 minute.
18. The method of claim 15 , wherein the treating of the tooth surface with fluoride one or more of:
reduces the incidence of dental caries,
remineralizes the tooth surface.
19. A kit comprising:
a colloid dispersion composition of claim 1 , and
instructions directing a user to treat a tooth surface with the colloid dispersion composition.
20. The colloid dispersion composition of claim 1 , wherein fluoride is released from the colloid dispersion composition at a rate of up to 93% in 1 minute according to the Fluoride Release Test.