METHODS TO INCREASE FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN BRONCHIETASIS PATIENTS WITH NONTUBERCULOUS MYCOBACTERIA
Provided herein are method of treating a patient with nontuberculous mycobacteria by administering nitric oxide to the patient for at least 100 days to increase functional capacity and quality of life of the patient.
1 . A method of treating a patient with nontuberculous mycobacteria, comprising: administering a therapeutic gas comprising nitric oxide to the patient for at least 100 days.
2 . The method of claim 1 , wherein the patient has cystic fibrosis, bronchiectasis, and/or chronic pulmonary disease.
3 . The method of claim 1 , wherein the nitric oxide is administered at a concentration of about 160 ppm.
4 . The method of claim 1 , wherein the therapeutic gas is administered twice daily.
5 . The method of claim 4 , wherein each administration is for at least 80 minutes.
6 . The method of claim 1 , wherein the therapeutic gas is administered three times daily.
7 . The method of claim 6 , wherein each administration is for at least 30 minutes.
8 . The method of claim 1 , wherein each administration is at least about 5 minutes and the patient has increased functional capacity after administration of the therapeutic gas.
9 . The method of claim 8 , wherein each administration of the therapeutic case is a concentration expressed relative per unit time of least about 3-5 ppm/minute, and the patient has an improved six minute walk test after administration of the therapeutic gas.
10 . The method of claim 9 , wherein the patient is able to walk a distance at least twice as far in six minutes after administration of the therapeutic gas as compared to prior to administration.
11 . The method of claim 1 , wherein the patient has improved quality of life after administration of the therapeutic gas.
12 . The method of claim 11 , wherein the patient has a lower chronic respiratory infection symptom score after administration of the therapeutic gas as compared to prior to administration.
13 . The method of claim 1 , wherein the administration of the therapeutic gas reduces the need for co-administration of antibiotics.
14 . The method of claim 1 , wherein the patient has an upregulation of methemoglobin reductase after administration of the therapeutic gas.
15 . A method of treating a patient with nontuberculous mycobacteria, comprising: administering a therapeutic gas comprising nitric oxide to the patient for at least 5 days.
16 . The method of claim 15 , wherein the nitric oxide is administered at a concentration from about 160 ppm to about 500 ppm.
17 . The method of claim 15 , wherein the nitric oxide is administered at a concentration from about 80 ppm to about 160 ppm.
18 . The method of claim 15 , wherein the therapeutic gas is administered at least once daily and each administration of the nitric oxide is for at least 5 minutes.
19 . The method of claim 15 , wherein the patient has an improved six minute walk test after administration of the therapeutic gas by at least 10% after administration of therapeutic gas.
20 . The method of claim 15 , wherein the patient has an improved CRISS score by at least 10% after administration of therapeutic gas.
21 . The method of claim 15 , wherein the patient has an improved methemogolbin reductase after administration of therapeutic gas.
22 . The method of claim 15 , wherein the therapeutic gas dosage as a concentration expressed relative per unit time is at least about 3-5 ppm/minute.
23 . A method of treating a patient with nontuberculous mycobacteria with intelligent dosing, comprising:
administering a therapeutic gas comprising nitric oxide to the patient for a first period of time of an administration of at least about 5 minutes,
evaluating one or more intelligent dosing factors including blood oxygen content, oxygen dilution, methemoglobin, methemoglobin reductase, CRISS score, or six minute walk performance; and,
administering a different amount of nitric oxide gas for a second period of time of at least about 5 days.
24 . The method of claim 23 , wherein the two administering steps each occur more than once over a prolonged period of time including at least about 5 days.