Electrospun PTFE coated stent and method of use
A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.
1. A vascular prosthesis, comprising:
a scaffolding structure configured to resist radial compression when disposed in a lumen of a patient, and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising a first layer of polytetrafluoroethylene (PTFE), a non-porous tie layer coupled to the first layer, and a second layer of porous PTFE,
wherein the non-porous tie layer is impervious to tissue growth into the non-porous tie layer, and
wherein portions of the tie layer are disposed within pores of the second layer.
2. The vascular prosthesis of claim 1 , wherein:
the first layer comprises serially deposited PTFE fibers.
3. The vascular prosthesis of claim 2 , wherein the serially deposited PTFE fibers are electrospun PTFE fibers.
4. The vascular prosthesis of claim 1 , wherein the first layer is permeable to tissue growth into the first layer.
5. The vascular prosthesis of claim 1 , wherein the first layer defines a luminal surface of the vascular prosthesis.
6. The vascular prosthesis of claim 1 , wherein the tie layer is non-fibrous.
7. The vascular prosthesis of claim 2 , wherein the second layer is permeable to tissue growth into the second layer.
8. The vascular prosthesis of claim 2 , wherein the second layer comprises serially deposited PTFE fibers.
9. The vascular prosthesis of claim 2 , wherein the second layer comprises electrospun PTFE fibers.
10. A medical appliance, comprising:
a scaffolding structure comprising a single wire; and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising:
a first layer of electrospun PTFE fibers;
a tie layer of fluorinated ethylene propylene (FEP) film coupled to the first layer; and
a second layer of porous PTFE,
wherein the tie layer is non-porous, and
wherein portions of the tie layer is disposed within pores of the second layer of porous PTFE.
11. The medical appliance of claim 10 , wherein the first layer defines a luminal surface of the medical appliance.
12. The medical appliance of claim 10 , wherein the first layer is permeable to tissue growth into the first layer.
13. The medical appliance of claim 10 , wherein the tie layer is impervious to tissue growth into the tie layer.
14. The medical appliance of claim 10 , wherein the tie layer is non-fibrous.
15. The medical appliance of claim 10 , wherein the second layer comprises electrospun PTFE fibers.
16. A medical stent, comprising:
a scaffolding structure comprising a wave configuration; and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising:
an inner layer of electrospun PTFE fibers;
a tie layer of FEP film coupled to the inner layer and impervious to tissue growth into the tie layer; and
an outer layer of electrospun PTFE fibers,
wherein the tie layer is non-porous, and
wherein portions of the tie layer is disposed within pores of the outer layer of electrospun PTFE.
17. The medical stent of claim 16 , wherein the inner layer defines a luminal surface of the medical stent.
18. The medical stent of claim 16 , wherein the inner layer is permeable to tissue growth into the inner layer.
19. The medical stent of claim 16 , wherein the tie layer is non-fibrous.
20. The medical stent of claim 16 , wherein the outer layer is permeable to tissue growth into the outer layer.