PEPTIDE COMPOSITIONS AND RELATED METHODS
Peptide compositions and methods for inhibiting neovascularization or development of pathological or aberrant blood vessels in human or other animal subjects.
1 .- 23 . (canceled)
24 . A method for inhibiting neovascularization or the development of pathological or aberrant blood vessels in a human or animal subject who is in need thereof, said method comprising the step of administering to the subject a therapeutically effective amount of a composition comprising a peptide which consists of or includes an amino acid sequence having the formula
Y—X—Z
wherein:
Y=R, H, K, Cys(acid), G or D;
X=G, A, Cys(acid), R, G, D or E; and
Z=Cys(acid), G, C, R, D, N or E.
25 . A method according to claim 24 wherein the composition further comprises taurine.
26 . A method according to claim 24 wherein the method is carried out to inhibit neovascularization or the development of pathological or aberrant blood vessels in the eye.
27 . A method according to claim 26 wherein the method is carried out to treat a disease or disorder selected from: diabetic retinopathy, neovascular age-related macular degeneration, retinopathy of prematurity (ROP), sickle cell retinopathy, retinal vein occlusion, ischemia-induced retinopathy and inflammatory diseases of the eye.
28 . A method according to claim 24 wherein the method is carried out to inhibit neovascularization or the development of pathological or aberrant blood vessels outside of the eye.
29 . A method according to claim 28 wherein the method is carried out to inhibit the growth or metastasis of a vascularized tumor.
30 . A method according to claim 24 wherein the peptide comprises R-G-Cys(acid)-G-G-G-D-G.
31 . A method according to claim 24 wherein the peptide comprises Cyclo-{R-G-Cys(acid)-F-N-Me-V}.
32 . A method according to claim 24 wherein the amino acid sequence is R-A-Cys (acid).
33 . A method according to claim 24 wherein the amino acid sequence is Cys(acid)-G-R.
34 . A method according to claim 24 wherein the peptide comprises Cyclo-{R-G-D-D-F-NMe-V}.
35 . A method according to claim 24 wherein the amino acid sequence is H-G-Cys(acid).
36 . A method according to claim 24 wherein the amino acid sequence is R-G-N.
37 . A method according to claim 24 wherein the amino acid sequence is D-G-R.
38 . A method according to claim 24 wherein the amino acid sequence is R-D-G.
39 . A method according to claim 24 wherein the amino acid sequence is R-A-E.
40 . A method according to claim 24 wherein the amino acid sequence is K-G-D.