Granted Patent B2

US 11,690,918 · App. 16/883,139 · Granted Jul 4, 2023

Inventors: Patricius Hendrikus Cornelis Van Berkel (Epalinges, CH); Philip Wilson Howard (Cambridge, GB)

Assignees: MEDIMMUNE LIMITED; ADC THERAPEUTICS S.A.

A61K47/6803A61K31/551A61K31/5517A61K45/06A61K47/6801A61K47/6849A61K47/6867C07K16/1063C07K16/2803C07K16/2851A61K39/001113A61K2039/505C07K2317/24C07K2317/40C07K2317/56C07K2317/73

Abstract

Claims (16)

1. A method of treating lymphoma or leukemia comprising administering to a patient a conjugate of formula ConjA:

wherein Ab is an antibody that binds to CD22 and comprises a VH domain having the amino acid sequence of SEQ ID NO. 1 and a VL domain having the amino acid sequence of SEQ ID NO. 2; and wherein the drug loading is an integer from 1 to 8.

2. The method of claim 1 , wherein the antibody is an intact antibody.

3. The method of claim 2 , wherein the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO. 3 paired with a light chain having the amino acid sequence of SEQ ID NO. 4.

4. The method of claim 3 , wherein the antibody comprises two heavy chains having the amino acid sequence of SEQ ID NO. 3, each paired with a light chain having the amino acid sequence of SEQ ID NO. 4.

5. The method of claim 1 , wherein the antibody is humanised, deimmunized, or resurfaced.

6. The method of claim 1 , wherein the drug loading is 1, 2, 3, or 4.

7. The method of claim 1 , wherein the lymphoma is a non-Hodgkin lymphoma.

8. The method of claim 7 , wherein the non-Hodgkin lymphoma is diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, (FL), Mantle Cell lymphoma (MCL), or chronic lymphatic lymphoma (CLL).

9. The method of claim 1 , wherein the leukemia is Hairy cell leukemia (HCL), Hairy cell leukemia variant (HCL-v), or Acute Lymphoblastic Leukaemia (ALL).

10. The method of claim 9 , wherein the leukemia is Acute Lymphoblastic Leukaemia (ALL).

11. The method of claim 1 , wherein the conjugate is of formula ConjE:

12. The method of claim 11 , wherein the lymphoma is a non-Hodgkin lymphoma.

13. The method of claim 12 , wherein the non-Hodgkin lymphoma is diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, (FL), Mantle Cell lymphoma (MCL), or chronic lymphatic lymphoma (CLL).

14. The method of claim 11 , wherein the leukemia is Hairy cell leukemia (HCL), Hairy cell leukemia variant (HCL-v), or Acute Lymphoblastic Leukaemia (ALL).

15. The method of claim 14 , wherein the leukemia is Acute Lymphoblastic Leukaemia (ALL).

Assignments (6)

Continuity (8)