SYSTEMS AND METHODS OF CLINICAL TRIAL EVALUATION

1 . A method of matching a patient to a clinical trial, the method comprising:

receiving text-based criteria for the clinical trial, including a molecular marker;

associating at least a portion of the text-based criteria to one or more pre-defined data fields containing molecular marker information;

comparing a molecular marker of the patient to the one or more pre-defined data fields; and

generating a report for a provider, the report based on the comparison and including a match indication of the patient to the clinical trial.

2 . The method of claim 1 , wherein the molecular marker is an RNA sequence.

3 . The method of claim 1 , wherein the molecular marker is a DNA sequence.

4 . The method of claim 1 , wherein the one or more pre-defined data fields include inclusion criteria and exclusion criteria.

5 . The method of claim 1 further comprising:

determining that the patient has not received a treatment related to the molecular marker of the patient; and

determining that the patient is eligible for at least one candidate clinical trial in response to determining that the patient has not received the treatment.

6 . The method of claim 1 , wherein at least a portion of the text based criteria is free-text.

7 . A clinical trial matching system comprising at least one processor and at least one memory, the system configured to:

receive text-based criteria for a clinical trial, including a molecular marker;

associate at least a portion of the text-based criteria to one or more pre-defined data fields containing molecular marker information;

compare a molecular marker of a patient to the one or more pre-defined data fields; and

generate a report for a provider, the report based on the comparison and including a match indication of the patient to the clinical trial.

8 . The system of claim 7 , wherein the molecular marker is an RNA sequence.

9 . The system of claim 7 , wherein the molecular marker is a DNA sequence.

10 . The system of claim 7 , wherein the one or more pre-defined data fields include inclusion criteria and exclusion criteria.

11 . The system of claim 7 , wherein the system is further configured to:

determine that the patient has not received a treatment related to the molecular marker of the patient; and

determine that the patient is eligible for at least one candidate clinical trial in response to determining that the patient has not received the treatment.

12 . The system of claim 7 , wherein at least a portion of the text based criteria is free-text.

13 . A method of matching a patient to a clinical trial, the method comprising:

receiving health information from an electronic medical record corresponding to the patient;

determining data elements within the health information using at least one of an optical character recognition (OCR) method and a natural language processing (NLP) method;

comparing the data elements to pre-determined trial criteria, including trial inclusion criteria and trial exclusion criteria;

determining at least one matching clinical trial, based on the comparing of the data elements to the predetermined trial criteria; and

notifying a practitioner associated with the patient of the at least one matching clinical trial.

14 . The method of claim 13 , wherein the pre-determined trial criteria is generated based on unstructured text.

15 . The method of claim 13 , wherein the pre-determined trial criteria is formatted in at least one standardized format in use by a medical institution.

16 . The method of claim 13 , wherein the data elements include at least one of a clinical feature, a molecular feature, an epigenome feature, a microbiome feature, an organoid feature, or an imaging feature.

17 . The method of claim 13 further comprising periodically updating a clinical trial database comprising the at least one matching clinical trial and at least one non-matching trial.

18 . The method of claim 13 , wherein notifying the practitioner associated with the patient of the at least one matching clinical trial comprises causing a report to be displayed to the practitioner, the report comprising the locations of the at least one matching trial.

19 . A clinical trial matching system comprising at least one processor and at least one memory, the system configured to:

receive health information from an electronic medical record corresponding to the patient;

determine data elements within the health information using at least one of an optical character recognition (OCR) method and a natural language processing (NLP) method;

compare the data elements to pre-determined trial criteria, including trial inclusion criteria and trial exclusion criteria;

determine at least one matching clinical trial, based on the comparing of the data elements to the predetermined trial criteria; and

notify a practitioner associated with the patient of the at least one matching clinical trial.

20 . The system of claim 19 , wherein the pre-determined trial criteria is generated based on unstructured text.

21 . The system of claim 19 , wherein the pre-determined trial criteria is formatted in at least one standardized format in use by a medical institution.

22 . The system of claim 19 , wherein the data elements include at least one of a clinical feature, a molecular feature, an epigenome feature, a microbiome feature, an organoid feature, or an imaging feature.

23 . The system of claim 19 , wherein the system is further configured to periodically update a clinical trial database comprising the at least one matching clinical trial and at least one non-matching trial.

24 . The system of claim 19 , wherein notifying the practitioner associated with the patient of the at least one matching clinical trial comprises causing a report to be displayed to the practitioner, the report comprising the locations of the at least one matching trial.