Biological deposit labeling and tracking including isotope, rare earth metal or mitochondria tags
Methods and systems are provided herein to track an original biological deposit that is withdrawn from a public repository. In some aspects, the public repository may include the ATCC or any other public repository in which biological materials are deposited for access by the general public. These techniques may be used to identify a product or biological deposit from a third party that is derived from the original biological deposit.
1. A method of tracking a biological deposit, the method comprising:
depositing a biological sample into a public repository, wherein the deposited biological sample comprises two or more tags selected from the group consisting of isotopes, rare earth metals, and mitochondria, and wherein the tags uniquely identify the biological sample among a population of deposited biological samples;
determining a ratio of the two or more tags of the deposited biological sample
storing, in a database, a profile comprising the tags for the deposited biological sample;
obtaining a test biological sample and analyzing the test biological sample for the presence of two or more tags;
determining a ratio of the two or more tags of the test biological sample
querying, using a processor, the database to determine whether the ratio of the two or more tags from the test biological sample match the ratio of the two or more tags of the deposited biological sample; and
upon matching the ratio of tags, validating that the test biological sample is produced or derived from the deposited biological sample.
2. The method of claim 1 , further comprising:
validating that the test biological sample is derived from the deposited biological sample when at least three types of tags of the test biological sample uniquely match the profile, wherein said profile is in a database of profiles.
3. The method of claim 1 , wherein the tags comprise at least three rare earth metals.
4. The method of claim 1 , wherein the tags comprise at least three isotopes.
5. The method of claim 1 , further comprising:
detecting the types of tags and the ratios of tags of the test biological sample with a measurement device; and
determining whether the detected types of tags and the ratios of the tags match the profile of the deposited biological sample.
6. The method of claim 1 , further comprising:
detecting the types of tags of the test biological sample with nucleic acid hybridization; and
determining whether the detected types of tags of the test biological sample match the profile of the deposited biological sample.
7. The method of claim 1 , wherein at least one of the two or more tags is mitochondria.
8. A method of tracking a biological deposit, the method comprising:
obtaining a test biological sample and analyzing the test biological sample for the presence of two or more tags, wherein the two or more tags are selected from the group consisting of isotopes, rare earth metals, and mitochondria;
determining a ratio of the two or more tags of the test biological sample;
querying, using a processor, a database to determine whether the ratio of the two or more tags from the test biological sample match profiles stored in a database, wherein each profile contains ratio of two or more tags of a deposited biological sample; and
upon matching the ratio of tags from the test biological sample with the ratio of tags of the deposited biological sample, validating that the test biological sample is produced or derived from the deposited biological sample.
9. The method of claim 8 , further comprising:
when at least three types of tags of the test biological sample uniquely match the tags of a profile, validating that the test biological sample is derived from the deposited biological sample.
10. The method of claim 8 , wherein the tags are selected from the group consisting of isotopes, primers, dyes, rare earth metals, and mitochondria.
11. The method of claim 8 , further comprising:
detecting the types of tags and the ratios of tags of the test biological sample with a measurement device; and
determining whether the detected types of tags and the ratios of the tags match the profile of the deposited biological sample.
12. The method of claim 8 , further comprising:
detecting the types of tags of the test biological sample with nucleic acid hybridization; and
determining whether the detected types of tags of the test biological sample match the profile of the deposited biological sample.