Stable pharmaceutical composition and methods of using same
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
1. A method of reducing triglyceride levels in a subject on statin therapy and having atrial fibrillation and triglycerides of greater than 500 mg/dl, the method comprising administering to the subject about 4 g of per day of ethyl eicosapentaenoate.
2. The method of claim 1 , wherein the subject has a baseline LDL-C level of about 40 mg/dL to about 100 mg/dL.
3. The method of claim 1 , wherein the ethyl eicosapentaenoate is present in a pharmaceutical composition and the ethyl eicosapentaenoate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.
4. The method of claim 3 , wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules.
5. The method of claim 1 , wherein the subject is administered the ethyl eicosapentaenoate for a period of at least about 2 years.
6. The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels by at least about 5% after administration of the ethyl eicosapentaenoate.
7. The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels by at least about 10% after administration of the ethyl eicosapentaenoate.
8. The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels by at least about 15% after administration of the ethyl eicosapentaenoate.
9. The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels by at least about 20% after administration of the ethyl eicosapentaenoate.