Rotational spun material covered medical appliances and methods of manufacture
A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.
1 . A medical appliance, comprising:
a first layer of rotational spun and serially deposited polytetrafluoroethylene (PTFE) fibers deposited in the absence of an electric field;
a tie layer coupled to the first layer and impervious to cell migration into the tie layer; and
a second layer of PTFE.
2 . The medical appliance of claim 1 , wherein the first layer is permeable to cell migration into the first layer.
3 . The medical appliance of claim 1 , wherein the first layer defines a luminal surface of the medical appliance.
4 . The medical appliance of claim 1 , wherein the tie layer comprises fluorinated ethylene propylene (FEP).
5 . The medical appliance of claim 1 , wherein the tie layer is non-porous and non-fibrous.
6 . The medical appliance of claim 1 , wherein the second layer is permeable to cell migration into the second layer.
7 . The medical appliance of claim 1 , wherein the second layer comprises expanded polytetrafluoroethylene (ePTFE).
8 . A medical appliance, comprising:
a first layer of rotational spun polymeric fibers;
a tie layer coupled to the first layer, wherein the tie layer is impervious to cellular migration into the tie layer; and
a second layer of PTFE.
9 . The medical appliance of claim 8 , wherein the first layer defines a luminal surface of the medical appliance.
10 . The medical appliance of claim 8 , wherein the rotational spun polymeric fibers are serially deposited in the absence of an electric field.
11 . The medical appliance of claim 8 , wherein the first layer is permeable to cell migration into the first layer.
12 . The medical appliance of claim 8 , wherein the first layer of rotational spun polymeric fibers comprise PTFE fibers.
13 . The medical appliance of claim 8 , wherein the tie layer is non-porous and non-fibrous.
14 . The medical appliance of claim 8 , wherein the second layer comprises ePTFE.
15 . A medical appliance, comprising:
a first layer of rotational spun PTFE fibers deposited in the absence of an electric field;
a tie layer of FEP coupled to the first layer and impervious to cell migration into the tie layer; and
a second layer of ePTFE.
16 . The medical appliance of claim 15 , wherein the first layer defines a luminal surface of the medical appliance.
17 . The medical appliance of claim 15 , wherein the first layer is permeable to cell migration into the first layer.
18 . The medical appliance of claim 15 , wherein the tie layer is non-porous and non-fibrous.
19 . The medical appliance of claim 15 , wherein the second layer is permeable to cell migration into the second layer.
20 . A medical appliance, comprising:
a first layer of serially deposited polytetrafluoroethylene (PTFE) fibers deposited in the absence of an electric field;
a tie layer comprising FEP, the tie layer coupled to the first layer and impervious to cell migration into the tie layer; and
a second layer of PTFE.
21 . The medical appliance of claim 1 , wherein the serially deposited PTFE fibers are rotational spun.
22 . The medical appliance of claim 1 , wherein the first layer is permeable to cell migration into the first layer.
23 . The medical appliance of claim 1 , wherein the first layer defines a luminal surface of the medical appliance.
24 . The medical appliance of claim 1 , wherein the tie layer is non-porous and non-fibrous.
25 . The medical appliance of claim 1 , wherein the second layer is permeable to cell migration into the second layer.
26 . The medical appliance of claim 1 , wherein the second layer comprises expanded polytetrafluoroethylene (ePTFE).