Device for delivery of rheumatoid arthritis medication
Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.
1. A device for delivering a rheumatoid arthritis drug through a stratum corneum to a subdermal location of a user, the device comprising:
a microneedle having an exterior surface;
a film disposed on the exterior surface of the microneedle, the film comprising:
a plurality of nanostructures, each nanostructure of the plurality of nanostructures having (i) a cross-sectional dimension less than about 500 nanometers and greater than about 5 nanometers and (ii) an aspect ratio from about 0.2 to about 5; and
a plurality of microstructures, each microstructure of the plurality of microstructures having (i) a cross-sectional dimension greater than about 500 nanometers and less than about 10 micrometers and (ii) an aspect ratio from about 0.15 to about 5; and
a rheumatoid arthritis drug in fluid communication with the microneedle.
2. The device of claim 1 wherein the plurality of nanostructures defines a plurality of first nanostructures, the device further comprising a plurality of second nanostructures, wherein each second nanostructure of the plurality of second nanostructures has a cross-sectional dimension less than the cross-sectional dimension of each microstructure of the plurality of microstructures and greater than the cross-sectional dimension of each nanostructure of the plurality of first nanostructures.
3. The device of claim 1 , wherein the exterior surface of the microneedle has an average surface roughness between about 10 nanometers and about 200 nanometers.
4. The device of claim 1 , wherein the exterior surface of the microneedle has an effective shear modulus between 4 MPa and 320 MPa.
5. The device of claim 1 , wherein each nanostructure of the plurality of nanostructures has a cross-sectional dimension from about 20 to about 400 nanometers, and wherein each microstructure of the plurality of microstructures has a cross-sectional dimension from about 600 nanometers to about 1.5 micrometers.
6. The device of claim 1 , wherein the rheumatoid arthritis drug is a disease-modifying antirheumatic drug.
7. The device of claim 6 , wherein the rheumatoid arthritis drug is a protein therapeutic.
8. The device of claim 7 , wherein the rheumatoid arthritis drug is a TNF-α blocker or an IL-1 blocker.
9. The device of claim 1 , wherein the rheumatoid arthritis drug is an anti-inflammatory drug.
10. The device of claim 1 , wherein the rheumatoid arthritis drug is an analgesic.
11. A device for delivering a rheumatoid arthritis drug through a stratum corneum to a subdermal location of a user, the device comprising:
a microneedle having an exterior surface;
a film disposed on the exterior surface of the microneedle, the film comprising:
a plurality of first nanostructures, wherein each nanostructure of the plurality of first nanostructures has (i) a cross-sectional dimension less than about 500 nanometers and greater than about 5 nanometers and (ii) an aspect ratio from about 0.2 to about 5;
a plurality of second nanostructures, wherein each second nanostructure of the plurality of second nanostructures has a cross-sectional dimension greater than the cross-sectional dimension of each first nanostructure of the plurality of first nanostructures; and
a plurality of microstructures, wherein each microstructure of the plurality of microstructures has a cross-sectional dimension greater than (i) the cross-sectional dimension of each first nanostructure of the plurality of first nanostructures and (ii) the cross-sectional dimension of each second nanostructure of the plurality of second nanostructures, wherein each microstructure of the plurality of microstructures further has a cross-sectional dimension treater than about 500 nanometers and less than about 10 micrometers; and
a rheumatoid arthritis drug in fluid communication with the microneedle.
12. The device of claim 11 , wherein each microstructure of the plurality of microstructures has a height from about 20 nanometers to about 1 micrometer.
13. The device of claim 11 , wherein the plurality of first nanostructures, the plurality of second nanostructures, and the plurality of microstructures are arranged to have a fractal dimension of about 2.5.
14. The device of claim 11 , wherein each second nanostructure of the plurality of second nanostructures defines a horizontal dimension that is about one third of a horizontal dimension corresponding to each microstructure of the plurality of microstructures.
15. The device of claim 11 , wherein each first nanostructure of the plurality of first nanostructures defines a horizontal dimension that is about one half of a horizontal dimension corresponding to each second nanostructure of the plurality of second nanostructures.
16. The device of claim 11 , wherein the rheumatoid arthritis drug is a disease-modifying antirheumatic drug.
17. The device of claim 16 , wherein the rheumatoid arthritis drug is a protein therapeutic.
18. The device of claim 17 , wherein the rheumatoid arthritis drug is a TNF-α blocker or an IL-1 blocker.
19. The device of claim 11 , wherein the rheumatoid arthritis drug is an anti-inflammatory drug.
20. The device of claim 11 , wherein the rheumatoid arthritis drug is an analgesic.