Granted Patent B2

US 12,447,188 · App. 16/900,863 · Granted Oct 21, 2025

Inventor: Stephen Thomas Woody (Asheville, NC)

Assignee: Avadim Holdings, Inc.

A61K36/886A61K9/0053A61K31/4166A61K47/02A61K47/10A61K47/12A61K47/183A61K47/186A61K47/22A61K47/24A61K47/26A61K47/34A61P31/02

Abstract

Claims (10)

1. A composition for treating the surface of inflamed chronically infected mammalian tissue, consisting of:

at least one ingredient selected from each of the following categories: an amphoteric surfactant category (a) ingredient having a wt % from about 2.0 to about 8.0 wt. %, a skin compatible anti-inflammatory category (b) ingredient having a wt % from about 6.0 to about 12.0 wt. %, and a skin compatible anti-foaming category (c) ingredient having a wt % from about 0.19 to about 0.27 wt. %;

at least one ingredient selected from each of the following categories: a cell growth promoting category (d) ingredient having a wt % from about 4.0 to about 10.0 wt. %, an immune system enhancing category (e) ingredient having a weight percentage from about 2.0 to about 5.0 wt. %, a fast acting skin compatible antimicrobial category (f) ingredient having a weight percentage from about 2.0 to about 10.0 wt. %, an absorption facilitation category (g) ingredient having a weight percentage from about 0.5 to about 5.0 wt. %, a humectant and emollient category (h) ingredient having a weight percentage from about 2.0 to about 11.0 wt. %, a free radical scavenging category (i) ingredient having a weight percentage from about 4.0 to about 8.0 wt. %, and a healing promoting category (j) ingredient having a weight percentage from about 2.0 to about 4.0 wt. %;

a biocompatible preservative category (k) ingredient of potassium sorbate having a weight percentage from about 0.01 to about 0.10 wt. %; and a plant based extract category (l) ingredient of olibanum (frankensense) having a weight percentage from about 0.009 wt. % to about 5.0 wt. %; with the balance of the composition being approximately 70 to 90 wt. % water;

wherein the composition has an acidic pH of from 4.0 to 5.0, is gamma irradiated at 4 kGY to 35 kGY to a sterility assurance level of 10 −2 to 10 −6 , and provides the hybrid benefits of: (1) treating microbials, (2) treating biofilms, (3) maintaining, nourishing and moisturizing, (4) maintaining the natural pH; (5) maintaining and promoting immunocompetency, and (6) protecting and preserving barrier function of the tissue's stratum corneum.

2. The composition of claim 1 wherein the category (a) ingredient is selected from the group consisting of cocamidopropyl betaine, cocamidopropyl hydroxysultaine, betaine alkyl glucosides, laurylglucosides, and combinations thereof; the category (b) ingredient is selected from the group consisting of aloe vera, allantoin, cocamidopropyl betaine, and mixtures thereof; the category (c) ingredient is selected from the group consisting of silicone-based antifoaming agents, dimethicone copolyol; the category (d) ingredient is selected from the group consisting of aloe vera, allantoin, beta glucan, a bioflavonoid, a polyphenolic compound, a grapefruit derived quaternary compound, and mixtures thereof; the category (e) ingredient is selected from the group consisting of aloe vera, beta glucan, colloidal silver, allantoin and mixtures thereof; the category (f) ingredient is selected from the group consisting of hepar sulphuris, camphor calcareum, xylitol, polyglyceryl-2-laurate, octenidine hydrochloride, Eucalyptus globulus , colloidal silver, a bioflavonoid, a polyphenolic compound, a grapefruit derived quaternary compound, grapefruit extract, and mixtures thereof; the category (g) ingredient is selected from the group consisting of beta glucan, aloe vera, colloidal silver, and mixtures thereof; the category (h) ingredient is selected from the group consisting of aloe vera, vitamin E, cocamidopropyl betaine, glycerin, fructooligosaccharides, decyl glucoside, diglycerin, Beta vulgaris root extract and mixtures thereof; the category (i) ingredient is selected from the group consisting of a bioflavonoid, a polyphenolic compound, a grapefruit derived quaternary compound, beta glucan, allantoin, vitamin E, Lactococcus ferment lysate, and mixtures thereof; the category (j) ingredient is selected from the group consisting of aloe vera, allantoin, beta glucan, and mixtures thereof.

3. The composition of claim 2 , wherein the composition does not contain grapefruit derived quaternary compounds.

4. The composition of claim 2 , wherein the composition does not contain a beta glucan.

5. The composition of claim 1 as a foam.

6. The composition of claim 1 as a spray.

Assignments (3)

Continuity (2)

References Cited (169)