IP Library › Granted Patent US 11,377,417
Granted Patent B2
US 11,377,417 · App. 16/904,786 · Granted Jul 5, 2022

Branched 3-phenylpropionic acid derivatives and their use

Inventors: Michael Hahn (Langenfeld, DE); Thomas Lampe (Duesseldorf, DE); Johannes-Peter Stasch (Solingen, DE); Karl-Heinz Schlemmer (Wuppertal, DE); Frank Wunder (Wuppertal, DE); Volkhart Min-Jian Li (Velbert, DE); Eva Maria Becker-Pelster (Wuppertal, DE); Friederike Stoll (Duesseldorf, DE); Andreas Knorr (Erkrath, DE); Elisabeth Woltering (Hilden, DE)
Assignee: Bayer Intellectual Property GmbH
C07C231/14A61K9/0053A61K31/196A61K45/06C07C233/55C07C235/38C07C2601/02C07C2601/04C07C2601/08
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Quick Facts
Patent No.
US 11,377,417
App. No.
16/904,786
Granted
Jul 5, 2022
Kind
B2
Abstract

The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Claims (9)

1. A compound having a formula selected from the group consisting of:

and hydrolysable ester derivatives thereof.

2. The compound of claim 1 having the formula

and hydrolysable ester derivatives thereof.

3. The compound of claim 1 having the formula

and hydrolysable ester derivatives thereof.

4. The hydrolysable ester derivative of the compound as defined in claim 1 .

5. A medicament comprising the compound as defined in claim 1 in combination with one or more inert, non-toxic, pharmaceutically suitable excipients.

6. A medicament comprising the compound as defined in claim 1 in combination with one or more further active compounds selected from the group consisting of organic nitrates, NO donors, cGMP-PDE inhibitors, stimulators of guanylate cyclase, agents having antithrombotic activity, agents lowering blood pressure, and agents altering lipid metabolisms.

Assignments (1)
CHANGE OF ADDRESS Recorded Jun 12, 2023
From: BAYER INTELLECTUAL PROPERTY GMBH
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 064021/0344 →