Method and apparatus for long-term assisting a left ventricle to pump blood
A method and apparatus for long-term assisting the left ventricle of a heart to pump blood is disclosed which includes at least one transluminally deliverable pump and a transluminally deliverable support structure which secures the at least one pump within the aorta for long-term use.
1. A blood flow assist system comprising:
a pump housing extending along a longitudinal axis in an axial direction between a first proximal end and a second distal end, the pump housing configured to be inserted into a blood vessel such that the second distal end is upstream of the first proximal end;
a pump disposed within the pump housing, the pump including an impeller that provides blood flow through the pump housing when rotated;
a motor configured to impart rotation to the impeller;
a power wire electrically connected to the motor, the motor disposed between the power wire and the pump housing, the power wire extending downstream relative to the first proximal end of the pump housing when the pump housing is inserted into a blood vessel; and
a support structure mechanically coupled to the pump housing and having a first collapsed configuration and a second expanded configuration, the support structure in the first collapsed configuration being sized for percutaneous transluminal delivery through a femoral or another peripheral artery of a circulatory system of a patient, the support structure in the second expanded configuration configured to extend between the pump housing and a portion of a descending aorta of the circulatory system of the patient,
wherein the support structure comprises a plurality of struts, each of at least two struts of the plurality of struts having an elongate body extending between a fixed end coupled with the pump housing and a free end disposed longitudinally away from the fixed end in the axial direction and overhanging the second distal end of the pump housing, the free end configured to be disposed upstream of the impeller when the pump housing is inserted into a blood vessel, the elongate body biased to cause the free end of the elongate body to spring radially outwardly to an expanded configuration toward an interior wall surface of the descending aorta to dispose the pump housing to be offset from the interior wall surface of the descending aorta, the at least two struts configured to allow placement in a sheath in the first collapsed configuration disengaged from the interior wall surface of the portion of the descending aorta and placement, upon deployment, in the second expanded configuration in which the respective free ends of the at least two struts contact the interior wall surface of the portion of the descending aorta while the respective fixed ends remain disposed at or adjacent to the pump housing, and
wherein each strut of the plurality of struts has a side surface spaced circumferentially apart from a side surface of an adjacent strut about the pump housing.
2. The blood flow assist system of claim 1 , wherein the at least two struts are configured to position the pump housing in a centrally spaced relationship from the interior wall surface of the descending aorta.
3. A blood flow assist system having a proximal end configured to be disposed outside a body of a patient and a distal end configured to be inserted in use into a vasculature of the patient, the blood flow assist system extending between the proximal end and the distal end along a longitudinal axis defining an axial direction, the blood flow assist system comprising:
a pump housing configured to be advanced with the distal end of the blood flow assist system into the vasculature;
a pump comprising an impeller disposed within the pump housing, the impeller providing blood flow when rotated; and
a support structure mechanically coupled to the pump housing and configured to secure the pump in a vessel of a circulatory system of a patient, wherein the support structure comprises a plurality of struts, at least one strut of the plurality of struts having a proximal portion coupled to the pump housing and a distal portion that is disposed distally of a distal end of the pump housing in the axial direction, each strut of the plurality of struts having a side surface spaced circumferentially apart from a side surface of an adjacent strut about the pump housing, the struts configured to allow placement in a sheath in a collapsed configuration in which the struts are disengaged from a vessel wall of the vessel and placement in an expanded configuration in which the struts contact the vessel wall.
4. The blood flow assist system of claim 3 , wherein the at least one strut is configured to position the pump housing in a centrally spaced relationship from the vessel wall of the vessel.
5. The blood flow assist system of claim 3 , further comprising a sheath, the sheath movable relative to the pump housing and the plurality of struts, the pump housing and the plurality of struts disposed at least partially within the sheath in an undeployed configuration of the blood flow assist system, the plurality of struts in the collapsed configuration when the blood flow assist system is in the undeployed configuration.
6. The blood flow assist system of claim 5 , wherein the pump housing and the plurality of struts are disposed distal of the sheath in a deployed configuration of the blood flow assist system, the plurality of struts in the expanded configuration when the blood flow assist system is in the deployed configuration.
7. The blood flow assist system of claim 3 , wherein the blood flow assist system allows, in the expanded configuration, except for the plurality of struts, unimpeded blood flow between an entirety of the pump housing and the vessel wall of the vessel at all times.
8. The blood flow assist system of claim 3 , further comprising an anchor element at the distal portion of the at least one strut, the anchor element configured to engage the at least one strut with the vessel wall of the vessel.
9. The blood flow assist system of claim 8 , wherein the anchor element comprises a hook.
10. A blood flow assist system comprising:
a power wire associated with a motor;
a pump housing having a first end coupled to the motor and extending along a longitudinal axis from the first end to a second end disposed away from the power wire, the second end comprising a fluid port for directing blood into or out of the blood flow assist system, wherein the pump housing, the motor, and a portion of the power wire are configured to be inserted into a blood vessel;
a pump disposed within the pump housing, the pump including an impeller that provides blood flow when rotated, the impeller disposed axially between the fluid port and the first end of the pump housing; and
a plurality of struts, each of at least two struts of the plurality of struts having an elongate body extending between a fixed end coupled with the pump housing and a free end disposed longitudinally away from the fixed end, the free end extending axially beyond a longitudinal position of the fluid port such that the fluid port is axially between the free end of the strut and the first end of the pump housing, the elongate body biased to cause the free end of the elongate body to spring radially outwardly to an expanded configuration toward an interior wall surface of the blood vessel to dispose the pump housing to be offset from the interior wall surface of the blood vessel.
11. The blood flow assist system of claim 10 , wherein the plurality of struts have a collapsed configuration in which the plurality of struts are disengaged from the interior wall surface of the blood vessel and disposed in a sheath.
12. The blood flow assist system of claim 11 , further comprising a sheath, the sheath movable relative to the pump housing and the plurality of struts, the pump housing and the plurality of struts disposed at least partially within the sheath in an undeployed configuration of the blood flow assist system, the plurality of struts in the collapsed configuration when the blood flow assist system is in the undeployed configuration.
13. The blood flow assist system of claim 12 , wherein the pump housing and the plurality of struts are disposed distal of the sheath in a deployed configuration of the blood flow assist system, the plurality of struts in the expanded configuration when the blood flow assist system is in the deployed configuration.
14. The blood flow assist system of claim 13 , wherein each of the at least two struts has a length disposed from the fixed end toward the free end, the length extending substantially parallel to the longitudinal axis in the undeployed configuration of the blood flow assist system, the length disposed from the free end to the fixed end extending at an acute angle relative to the longitudinal axis in the deployed configuration.
15. The blood flow assist system of claim 10 , wherein the blood flow assist system allows, except for the plurality of struts, unimpeded blood flow between an entirety of the pump housing and the interior wall surface of the blood vessel at all times in the expanded configuration.
16. The blood flow assist system of claim 10 , further comprising an anchor element at the free end of each of the at least two struts, the anchor element-configured to engage the at least two struts with the interior wall surface of the blood vessel.
17. The blood flow assist system of claim 16 , wherein the anchor element comprises a hook.
18. The blood flow assist system of claim 10 , further comprising a second plurality of struts extending from the pump housing, the second plurality of struts extending along the longitudinal axis in an opposite direction from the plurality of struts.
19. The blood flow assist system of claim 10 , wherein the impeller provides axial blood flow when rotated.
20. The blood flow assist system of claim 19 , wherein the motor is configured to impart rotation to the impeller and the power wire is configured to extend downstream relative to the first end of the pump housing.
21. A blood flow assist system comprising:
a pump housing extending along a longitudinal axis in an axial direction between a first end and a second end, the second end comprising a fluid port for directing blood into or out of the blood flow assist system;
a pump comprising an impeller disposed within the pump housing, the impeller providing blood flow when rotated, the impeller disposed axially between the fluid port and the first end of the pump housing; and
a support structure mechanically coupled to the pump housing and configured to secure the pump in a vessel of a circulatory system of a patient, wherein the support structure comprises a plurality of struts, at least one strut of the plurality of struts having an inner end coupled to the pump housing and an outer end, the at least one strut extending from the inner end in the axial direction axially beyond a longitudinal position of the fluid port to the outer end such that the fluid port is axially between the outer end of the strut and the first end of the pump housing, the struts configured to allow placement in a sheath in a radially collapsed configuration disengaged from a vessel wall of the vessel and placement in a radially expanded configuration in which the respective outer ends of the struts contact the vessel wall upon movement in a radial direction transverse to the axial direction.
22. The blood flow assist system of claim 21 , wherein the plurality of struts have a collapsed configuration in which the plurality of struts are disengaged from the vessel wall of the vessel.
23. The blood flow assist system of claim 21 , further comprising a sheath, the sheath movable relative to the pump housing and the plurality of struts, the pump housing and the plurality of struts disposed at least partially within the sheath in an undeployed configuration of the blood flow assist system, the plurality of struts in the collapsed configuration when the blood flow assist system is in the undeployed configuration.
24. The blood flow assist system of claim 23 , wherein the pump housing and the plurality of struts are disposed distal of the sheath in a deployed configuration of the blood flow assist system, the plurality of struts in the expanded configuration when the blood flow assist system is in the deployed configuration.
25. The blood flow assist system of claim 21 , further comprising a motor coupled to the pump housing, the motor configured to impart rotation to the impeller.
26. The blood flow assist system of claim 25 , further comprising a power wire electrically connected to the motor, the power wire extending downstream of the pump housing in use.
27. The blood flow assist system of claim 21 , further comprising an anchor element at the outer end of each of the strut, the anchor element configured to engage the strut with the vessel wall of the blood vessel.
28. The blood flow assist system of claim 27 , wherein the anchor element comprises a hook.
29. The blood flow assist system of claim 21 , wherein the impeller provides axial blood flow when rotated.
30. The blood flow assist system of claim 21 , wherein the blood flow assist system allows, except for the plurality of struts, unimpeded blood flow between an entirety of the pump housing and the vessel wall of the blood vessel at all times in the expanded configuration.