IP Library Patent Application 16908919
Patent Application
App. No. 16/908,919

COMPOSITIONS COMPRISING BACTERIAL STRAINS

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Quick Facts
Patent No.
US None
App. No.
16/908,919
Abstract

The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.

Claims (18)

1 .- 30 . (canceled)

31 . A method of treating a subject in need thereof, comprising:

administering to said subject a pharmaceutical composition that comprises at least 1×10 3 colony forming units (CFU)/g of a bacteria strain of the genus Erysipelatoclostridium with respect to a total weight of said pharmaceutical composition,

wherein said bacteria strain comprises a polynucleotide of a 16S rRNA gene that has at least 95% identity to the polynucleotide sequence of SEQ ID NO:3, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a BLOSUM of 62, and

wherein said pharmaceutical composition comprises said bacteria strain in a therapeutically effective amount that is sufficient to treat said subject when administered to said subject.

32 . The method of claim 31 , wherein said bacteria strain is capable of at least partially colonizing an intestine of said subject.

33 . The method of claim 31 , wherein said pharmaceutical composition is formulated for delivery to an intestine of said subject.

34 . The method of claim 31 , wherein said pharmaceutical composition is encapsulated.

35 . The method of claim 31 , wherein said bacterial strain is dried.

36 . The method of claim 31 , wherein said administering comprises oral, rectal, nasal, buccal, sublingual, or subcutaneous administration.

37 . The method of claim 31 , wherein said pharmaceutical composition further comprises a pharmaceutically acceptable excipient, diluent, or carrier.

38 . The method of claim 31 , wherein said pharmaceutical composition comprises from about 1×10 3 to about 1×10 11 CFU/g of the bacteria strain with respect to the total weight of said pharmaceutical composition.

39 . The method of claim 31 , wherein said bacteria strain comprises a polynucleotide of a 16S rRNA gene that has at least 99% identity to the polynucleotide sequence of SEQ ID NO:3, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a BLOSUM of 62.

40 . The method of claim 31 , wherein said bacteria strain comprises a 16S rRNA gene that comprises the polynucleotide sequence of SEQ ID NO: 3.

41 . The method of claim 31 , wherein said bacteria strain is the strain deposited with the NCIMB accession number NCIMB 42688.

42 . The method of claim 31 , wherein said bacteria strain is of species Erysipelatoclostridium ramosum.

43 . The method of claim 31 , wherein said bacteria strain is a spore-forming bacterial strain.

44 . The method of claim 31 , wherein said subject is human.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2023
From: 4D PHARMA PLC; 4D PHARMA RESEARCH LIMITED
To: CJ BIOSCIENCE, INC.
Reel/Frame 063992/0427 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2022
From: OXFORD FINANCE LUXEMBOURG S.A R.L.
To: ARMISTICE CAPITAL MASTER FUND LTD.
Reel/Frame 061806/0371 →
INTELECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 30, 2021
From: 4D PHARMA PLC; 4D PHARMA RESEARCH LIMITED; 4D PHARMA CORK LIMITED; 4D PHARMA DELAWARE INC.
To: OXFORD FINANCE LUXEMBOURG S.A R.L.
Reel/Frame 057042/0715 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2020
From: MULDER, IMKE ELISABETH; HOLT, AMY BETH; MCCLUSKEY, SEANIN MARIE; LENNON, GRAINNE CLARE; AHMED, SUAAD
To: 4D PHARMA RESEARCH LIMITED
Reel/Frame 054595/0460 →