GATA3 inhibitors for the promotion of subcutaneous fat deposition
Methods and compositions using dnayzme-based GATA3 inhibitors for the treatment of insulin resistance and Type II diabetes, for the stimulation of adipogenesis in vivo, and for the promotion of fat redistribution are disclosed.
1. A method of stimulating adipogenesis in buttocks, thighs, breast, neck, back of hands, or feet of a human subject, the method comprising:
subcutaneously administering a composition to or adjacent to the buttocks, thighs, breast, neck, back of hands, or feet, wherein said composition comprises one or more dnazyme-based GATA-3 inhibitors selected from the group consisting of SEQ ID NOs. 1-151.
2. A method of increasing adipogenic capacity in cells in buttocks, thighs, breasts, neck, hack of hands, or feet of a human subject, the method comprising:
subcutaneously administering a composition to or adjacent to the buttocks, thighs, breasts, back of hands, or feet of the human subject, wherein said composition comprises one or more dnazyme-based GATA-3 inhibitors selected from the group consisting of SEQ ID NOs. 1-151.