Method of providing celiprolol therapy to a patient
View Patent ↗The present disclosure relates to the field of treatment of an orphan disease, in particular treatment of vascular Ehlers-Danlos syndrome (vEDS). More specifically, the present disclosure relates to novel up-titration dosage regimens (e.g., escalating dosage regimens) effective for treating vEDS patients with celiprolol.
1. A method for treating vascular Ehlers-Danlos syndrome, comprising administering to a patient in need thereof an initial daily dose of about 91.25 mg celiprolol, or an equivalent amount of a pharmaceutically acceptable salt thereof, for about 1 month, followed by administering to the patient a second daily dose of about 182.5 mg celiprolol, or an equivalent amount of a pharmaceutically acceptable salt thereof, for about 1 month, followed by administering to the patient a third daily dose of about 273.75 mg celiprolol, or an equivalent amount of a pharmaceutically acceptable salt thereof, for about 1 month, followed by administering to the patient a fourth daily dose of about 365 mg celiprolol, or an equivalent amount of a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the second daily dose is administered twice daily.
3. The method of claim 2 , wherein the fourth daily dose is administered twice daily.
4. The method of claim 1 , wherein the fourth daily dose is administered for at least 1 year.
5. The method of claim 1 , wherein the fourth daily dose is administered for at least 5 years.
6. The method of claim 1 , wherein the patient is 15-years old or older.
7. The method of claim 1 , wherein the treatment is initiated as soon as vascular EDS is diagnosed, or when the patient is 10 years old.
8. A method for treating vascular Ehlers-Danlos syndrome, comprising administering to a patient in need thereof an initial daily dose of about 100 mg celiprolol hydrochloride for about 1 month, followed by administering to the patient a second daily dose of about 200 mg celiprolol hydrochloride for about 1 month, followed by administering to the patient a third daily dose of about 300 mg celiprolol hydrochloride for about 1 month, followed by administering to the patient a fourth daily dose of about 400 mg celiprolol hydrochloride.
9. The method of claim 8 , wherein the initial daily dose is administered at about 100 mg once daily.
10. The method of claim 8 , wherein the second daily dose is administered at about 100 mg twice daily.
11. The method of claim 8 , wherein the fourth daily dose is administered at about 200 mg twice daily.
12. The method of claim 8 , wherein the fourth daily dose is administered for at least 1 year.
13. The method of claim 8 , wherein the fourth daily dose is administered for at least 5 years.
14. The method of claim 8 , wherein the patient is 15-years old or older.
15. The method of claim 8 , wherein the treatment is initiated as soon as vascular EDS is diagnosed, or when the patient is 10 years old.