PKM2 MODULATORS AND METHODS FOR THEIR USE
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
1 - 90 . (canceled)
91 . A pharmaceutical formulation comprising one or more compounds of the following structures:
or a pharmaceutically acceptable salt thereof.
92 . A method of treating cancer in a mammal in need thereof, the method comprising providing a therapeutically effective amount of the pharmaceutical formulation of claim 91 to the subject.