DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
1 . An inhaler, comprising:
a housing,
a mouthpiece, and
a sled or slide tray,
wherein the sled or slide tray is attached to the mouthpiece by a cam, a gear, or a combination thereof and moveably attached to the housing.
2 . The inhaler of claim 1 , further including a cartridge.
3 . The inhaler of claim 2 , wherein the sled or slide tray is configured to reconfigure the cartridge upon movement of the mouthpiece.
4 . The inhaler of claim 2 , wherein the sled or slide tray is configured to reconfigure the cartridge upon movement of the housing.
5 . The inhaler of claim 2 , wherein the cartridge includes a medicament.
6 . The inhaler of claim 5 , wherein the medicament comprises an active ingredient.
7 . The inhaler of claim 6 , wherein the active ingredient is a hormone, an anticoagulant, an immunomodulating agent, a vaccine, a small molecule, a cytotoxic agent, an antibiotic, a vasoactive agent, a neuroactive agent, an anaesthetic, sedative, a steroid, a decongestant, an antiviral, an antisense, an antigen, or an antibody.
8 . The inhaler of claim 6 , wherein the active ingredient is insulin, heparin, calcitonin, felbamate, sumatriptan, parathyroid hormone, growth hormone, erythropoietin, AZT, DDI, granulocyte macrophage colony stimulating factor, lamotrigine, chorionic gonadotropin releasing factor, luteinizing releasing hormone, beta-galactosidase, exendin, vasoactive intestinal peptide, follicle stimulating hormone, vasoactive intestinal peptide, parathyroid hormone, parathyroid hormone related protein, glucagon-like peptide-1, exendin, oxyntomodulin, a small molecule, peptide YY, interleukin 2-inducible tyrosine kinase, Bruton's tyrosine kinase, inositol-requiring kinase 1, PC-DAC-modified derivative, or O-glycosylated forms of PC-DAC, parathyroid hormone 1-34, argatroban, or a combination thereof.
9 . The inhaler of claim 6 , wherein the active ingredient is insulin.
10 . The inhaler of claim 6 , wherein the active ingredient is oxyntomodulin.
11 . The inhaler of claim 6 , wherein the active ingredient is glucagon-like peptide-1.
12 . The inhaler of claim 5 , wherein the medicament comprises a diketopiperazine.
13 . The inhaler of claim 12 , wherein the diketopiperazine is
14 . A method of using an inhaler, the method comprising:
moving a sled or slide within a housing and attached to a mouthpiece by a cam, a gear, or a combination thereof.
15 . The method of claim 14 , wherein the inhaler further includes a cartridge.
16 . The method of claim 15 , wherein the cartridge is reconfigured by moving the sled or slide tray.
17 . The method of claim 15 , wherein the sled or slide tray is moved by movement of the mouthpiece.
18 . The method of claim 15 , wherein the sled or slide tray is moved by movement of the housing.
19 . The method of claim 15 , wherein the cartridge includes a hormone, an anticoagulant, an immunomodulating agent, a vaccine, a cytotoxic agent, an antibiotic, a vasoactive agent, a neuroactive agent, an anaesthetic, sedative, a steroid, a decongestant, an antiviral, an antisense, an antigen, an antibody, insulin, heparin, calcitonin, felbamate, sumatriptan, parathyroid hormone, growth hormone, erythropoietin, AZT, DDI, granulocyte macrophage colony stimulating factor, lamotrigine, chorionic gonadotropin releasing factor, luteinizing releasing hormone, beta-galactosidase, exendin, vasoactive intestinal peptide, follicle stimulating hormone, vasoactive intestinal peptide, parathyroid hormone, parathyroid hormone related protein, glucagon-like peptide-1, exendin, oxyntomodulin, a small molecule, peptide YY, interleukin 2-inducible tyrosine kinase, Bruton's tyrosine kinase, inositol-requiring kinase 1, PC-DAC-modified derivative, or O-glycosylated forms of PC-DAC, parathyroid hormone 1-34, argatroban, or a combination thereof.
20 . The method of claim 15 , wherein the cartridge includes