Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by

1. A method for treating disorders associated to the inflammation induced by P. acnes comprising administering to a subject in need thereof an effective amount of a compound of following general formula (Ib):

or a pharmaceutically acceptable salt and/or solvate thereof, wherein

R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, —NO 2 , —CN, —OR 25 , —NR 26 R 27 , —C(O)OR 28 , —S(O) 2 R 29 , or a (C 1 -C 6 )alkyl group optionally substituted with one or several groups selected from halo or —OR 30 ,

R 5 to R 9 are, independently of one another, hydrogen atom, halo, —CN, —NO 2 , —OR 12 , —NR 13 R 14 , —C(O)OR 15 , —C(O)NR 16 R 17 , —S(O) 2 NR 18 R 19 , —S(O) 2 R 20 , —NHS(O) 2 R 21 , —NHC(O)R 22 , or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, —OR 23 or —OC(O)R 24 ; or the couple R 5 -R 6 , R 6 -R 7 , R 7 -R 8 or R 8 -R 9 form together with the carbon atoms to which they are chemically linked, an heterocycle, while the others are hydrogen atoms,

R 12 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, CF 3 or —OR 31 , and

R 31 is hydrogen atom, halo or a (C 1 -C 6 )alkyl group.

2. The method of claim 1 , wherein R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, —NO 2 , —CN, —OR 25 , —NR 26 R 27 or a (C 1 -C 6 )alkyl group; R 25 to R 27 being as defined in claim 1 .

3. The method of claim 1 , wherein R 5 to R 9 are, independently of one another, hydrogen atom, halo, —CN, —NO 2 , —OR 12 , —NR 13 R 14 , —C(O)NR 16 R 17 , —S(O) 2 NR 18 R 19 , or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle or (C 1 -C 6 )alkyl-heterocycle; and R 12 to R 14 and R 16 to R 19 are defined as in claim 1 .

4. The method of claim 1 , wherein R 12 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6 )alkyl.

5. The method of claim 1 , wherein said compound of formula (I) is a compound of the following formula (Ic):

or a pharmaceutically acceptable salt and/or solvate thereof.

6. A method for treating disorders associated to the inflammation induced by P. acnes comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising at least one compound of claim 1 at least one pharmaceutically acceptable excipient.

7. The method of claim 6 , wherein said composition further comprises another active principle.

8. The method of claim 1 , wherein said disorders associated to the inflammation induced by P. acnes are acne, psoriasis, chronic urticaria, urticaria pigmentosa, cutaneous autoinflammatory diseases, hidradenitis, or atopic dermatitis.

9. The method of claim 1 , wherein said compound is the dihydrochloride salt of compound (Ic):

10. The method of claim 6 , wherein said disorders associated to the inflammation induced by P. acnes are acne, psoriasis, chronic urticaria, urticaria pigmentosa, cutaneous autoinflammatory diseases, hidradenitis, or atopic dermatitis.

11. The method of claim 7 , wherein the another active principle is selected from topical antibiotic, topical anti-inflammatory, topical anti-seborrheic, zinc derivatives, cyclins, and isotretinoin.

12. The method of claim 7 , wherein the another active principle is selected from erythromycine, dalacine, benzoyl peroxydes derivatives, tretinoin, adapalene, zinc gluconate, cyclins, and isotretinoin.