IP Library Granted Patent US 11,918,389
Granted Patent B2
US 11,918,389 · App. 16/936,550 · Granted Mar 5, 2024

Breast biopsy and needle localization using tomosynthesis systems

Inventors: Kenneth Defreitas (Patterson, NY); John Laviola (Orange, CT); Loren Thomas Niklason (Hillsborough, NC); Tao Wu (Brookfield, CT); Joseph Mark (Indianapolis, IN); Michael Miller (Trafalgar, IN); Jay Stein (Boston, MA); Andrew Smith (Lexington, MA)
Assignee: Hologic, Inc.
A61B6/025A61B6/0435A61B6/463A61B6/466A61B6/467A61B6/469A61B6/502A61B6/542A61B10/0041A61B10/0233A61B10/0275A61B90/11A61B90/17A61B6/0414A61B6/12A61B6/481A61B2090/376
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Quick Facts
Patent No.
US 11,918,389
App. No.
16/936,550
Granted
Mar 5, 2024
Kind
B2
Abstract

Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Claims (51)

1. A method for displaying contrast tomosynthesis reconstructed images of a breast of a patient, the method comprising:

performing a tomosynthesis scan of the breast while the breast contains a contrast agent, the tomosynthesis scan comprising:

moving an imaging x-ray source through a plurality of imaging positions along a source trajectory; and

obtaining a plurality of images corresponding to each of the plurality of imaging positions, wherein the plurality of images includes a first set of images and a second set of images;

based on the first set of images and the second set of images, deriving tomosynthesis reconstructed images representing respective slices of the breast;

displaying at least one of the tomosynthesis reconstructed images of the breast;

receiving an indication on at least one of the tomosynthesis reconstructed images of an area of interest within the breast;

determining, from the indication, three-dimensional coordinates of the area of interest;

positioning an insertable artificial element at the area of interest in the breast, based on the three-dimensional coordinates of the area of interest; and

emitting, after positioning the insertable artificial element, a plurality of verification x-ray beams of a same image type along a verification imaging trajectory from the imaging x-ray source at a plurality of verification x-ray positions, wherein at least two of the plurality of verification x-ray beams corresponds to at least a first x-ray dose and a second x-ray dose different than the first x-ray dose.

2. The method of claim 1 , wherein the plurality of verification imaging positions are disposed along the verification imaging trajectory.

3. The method of claim 1 , wherein the insertable artificial element is one of:

a needle;

a wire; or

a marker.

4. The method of claim 3 , wherein the insertable artificial element is the needle, and the verification imaging trajectory is disposed asymmetrically to the needle.

5. The method of claim 3 , wherein the insertable artificial element is the needle, and the needle is positioned in one of the following positions prior to emission of the verification x-ray beam:

a pre-extended position; or

an extended position.

6. The method of claim 1 , wherein emitting the verification x-ray beam at the plurality of verification imaging positions comprises emitting a first x-ray beam on a first side of the insertable artificial element and emitting a second x-ray beam on a second side of the insertable artificial element.

7. The method of claim 1 , the method further comprising:

performing a biopsy at a location of the insertable artificial element.

8. A method for displaying contrast tomosynthesis reconstructed images of a breast of a patient, the method comprising:

performing a tomosynthesis scan of the breast while the breast contains a contrast agent, the tomosynthesis scan comprising:

moving an imaging x-ray source through a plurality of imaging positions along a source trajectory; and

obtaining a plurality of images corresponding to each of the plurality of imaging positions, wherein the plurality of images includes a first set of images and a second set of images;

based on the first set of images and the second set of images, deriving tomosynthesis reconstructed images representing respective slices of the breast;

displaying at least one of the tomosynthesis reconstructed images of the breast;

receiving an indication on at least one of the tomosynthesis reconstructed images of an area of interest within the breast;

determining, from the indication, three-dimensional coordinates of the area of interest;

positioning an insertable artificial element at the area of interest in the breast, based on the three-dimensional coordinates of the area of interest; and

emitting a plurality of verification x-ray beams along a verification imaging trajectory from the imaging x-ray source at a plurality of verification x-ray positions, wherein at least two of the plurality of verification x-ray beams corresponds to at least a first x-ray dose and a second x-ray dose different than the first x-ray dose;

wherein the verification imaging trajectory is disposed asymmetrically to the insertable artificial element.

9. The method of claim 8 , wherein the plurality of verification imaging positions are disposed along the verification imaging trajectory.

10. The method of claim 8 , wherein the insertable artificial element is one of:

a needle;

a wire; or

a marker.

11. The method of claim 10 , wherein the insertable artificial element is the needle.

12. The method of claim 10 , wherein the insertable artificial element is the needle, and the needle is positioned in one of the following positions prior to emission of the verification x-ray beam:

a pre-extended position; or

an extended position.

13. The method of claim 8 , wherein emitting the verification x-ray beam at the plurality of verification imaging positions comprises emitting a first x-ray beam on a first side of the insertable artificial element and emitting a second x-ray beam on a second side of the insertable artificial element.

14. The method of claim 8 , the method further comprising:

performing a biopsy at a location of the insertable artificial element.

15. The method of claim 8 , wherein the insertable artificial element includes a tip for cutting a tissue and a stem for blocking or scattering x-rays.

16. The method of claim 15 , wherein the tip includes metallic material, and the stems includes x-ray transparent material.

17. The method of claim 15 , wherein the stem further includes an x-ray opaque rib.

18. The method of claim 17 , wherein the rib includes metallic material.

19. The method of claim 17 , wherein the rib is configured to be removed from the stem after firing the insertable artificial element.

20. The method of claim 15 , wherein the stem includes a first body and a second body, the first and second bodies are coaxial, the first body includes an x-ray transparent layer the second body includes an x-ray opaque layer.

Assignments (4)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 054089/0804 Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC; GEN-PROBE PRODESSE, INC.
Reel/Frame 075504/0575 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2022
From: DEFREITAS, KENNETH F.; LAVIOLA, JOHN; NIKLASON, LOREN THOMAS; WU, TAO; MARK, JOSEPH L.; MILLER, MICHAEL E.; STEIN, JAY A.; SMITH, ANDREW P.
To: HOLOGIC, INC.
Reel/Frame 062169/0062 →
SECURITY INTEREST Recorded Oct 15, 2020
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 054089/0804 →