Applying tumor treating fields (TTFields) via electrodes embedded into skull implants
Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.
1. An apparatus comprising
a rigid substrate shaped and dimensioned to replace a section of a skull, the substrate having an inner side and an outer side opposed to the inner side;
an electrically conductive plate having an inner side and an outer side, wherein the outer side of the plate is affixed to the inner side of the substrate;
a dielectric layer disposed on the inner side of the plate; and
an electrically conductive lead having an inner end and an outer end, wherein the inner end of the lead is disposed in electrical contact with the plate, wherein the lead passes through the substrate from a point on the inner side of the substrate to a point on the outer side of the substrate, and wherein the outer end of the lead extends outwardly from the outer side of the substrate and is configured to accept an electrical signal from an external device.
2. The apparatus of claim 1 , further comprising a temperature sensor positioned adjacent to the dielectric layer.
3. The apparatus of claim 2 , further comprising at least one wire that passes through the substrate and terminates at the temperature sensor, wherein the wire is configured to transmit an electrical signal from the temperature sensor to the external device.
4. The apparatus of claim 3 , wherein the temperature sensor comprises a thermistor.
5. The apparatus of claim 1 , wherein the dielectric layer comprises a ceramic layer with a dielectric constant of at least 10,000.
6. The apparatus of claim 1 , wherein the dielectric layer comprises a flexible thin layer of high dielectric polymer.
7. An apparatus comprising:
a rigid substrate shaped and dimensioned to replace a section of a skull, the substrate having an inner side and an outer side opposed to the inner side;
a plurality of electrically conductive plates, each having an inner side and an outer side, wherein the outer side of each plate is affixed to the inner side of the substrate;
a dielectric layer disposed on the inner side of each plate; and
a first electrically conductive lead having an inner end and an outer end, wherein the inner end of the first lead is disposed in electrical contact with a first one of the plates, wherein the first lead passes through the substrate from a first point on the inner side of the substrate to a second point on the outer side of the substrate, and wherein the outer end of the first lead extends outwardly from the outer side of the substrate and is configured to accept an electrical signal from an external device.
8. The apparatus of claim 7 , further comprising a second electrically conductive lead having an inner end and an outer end, wherein the inner end of the second lead is disposed in electrical contact with a second one of the plates, wherein the second lead passes through the substrate from a third point on the inner side of the substrate to a fourth point on the outer side of the substrate, and wherein the outer end of the second lead is configured to accept an electrical signal from the external device.
9. The apparatus of claim 7 , further comprising an additional electrically conductive lead disposed to electrically connect the first one of the plates with a second one of the plates.
10. The apparatus of claim 7 , further comprising a temperature sensor positioned adjacent to the dielectric layer.
11. The apparatus of claim 10 , further comprising at least one wire that passes through the substrate and terminates at the temperature sensor, wherein the wire is configured to transmit an electrical signal from the temperature sensor to the external device.
12. The apparatus of claim 11 , wherein the temperature sensor comprises a thermistor.
13. The apparatus of claim 7 , wherein the dielectric layer comprises a ceramic layer with a dielectric constant of at least 10,000.
14. The apparatus of claim 7 , wherein the dielectric layer comprises a flexible thin layer of high dielectric polymer.