IP Library Granted Patent US 11,402,330
Granted Patent B2
US 11,402,330 · App. 16/937,905 · Granted Aug 2, 2022

Method for measuring optical signal detector performance

Inventors: David Opalsky (San Diego, CA); Srajan Raghuwanshi (Escondido, CA); James Bui (San Diego, CA)
Assignee: GEN-PROBE INCORPORATED
G01N21/645G01N21/0332G01N21/276G01N21/75G01N35/025G01N35/00732G01N2021/6441G01N2035/00356G01N2035/0455G01N2035/0475G01N2035/0484G01N2201/0407G01N2201/0415G01N2201/12723
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Quick Facts
Patent No.
US 11,402,330
App. No.
16/937,905
Granted
Aug 2, 2022
Kind
B2
Abstract

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

Claims (26)

1. A method for measuring optical signal detector performance, comprising:

directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector;

measuring a first characteristic of light detected by a first sensor of the first optical signal detector while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector;

directing light emitted from the optical signal detector into a first void in the first detection zone of the optical signal detector;

measuring a second characteristic of light detected by the first sensor of the optical signal detector while the first void is in the first detection zone of the optical signal detector; and

determining an operational performance status of the optical signal detector based on at least one of the first characteristic and the second characteristic.

2. The method of claim 1 , wherein the first measured characteristic is a first intensity of light and the second measured characteristic is a second intensity of light.

3. The method of claim 1 , wherein determining the operational performance status of the optical signal detector based on at least one of the first measured characteristic and the second measured characteristic comprises determining whether the first measured characteristic is within a first predetermined non-fluorescent-surface characteristic range.

4. The method of claim 1 , wherein determining the operational performance status of the optical signal detector based on at least one of the first measured characteristic and the second measured characteristic comprises determining whether the second measured characteristic is within a first predetermined void characteristic range.

5. The method of claim 1 , further comprising determining the operational performance status of the optical signal detector based on both the first measured characteristic and the second measured characteristic.

6. The method of claim 1 , wherein the operational performance status is a proper operational performance status, a failure status, or a deteriorated performance status.

7. The method of claim 6 , wherein the operational performance status is the proper operational performance status.

8. The method of claim 6 , wherein the operational performance status is the failure status.

9. The method of claim 6 , wherein the operational performance status is the deteriorated performance status.

10. The method of claim 1 , wherein the optical signal detector is a fluorometer.

11. The method of claim 1 , further comprising:

directing light emitted from the optical signal detector onto a second non-fluorescent surface portion in a second detection zone of the optical signal detector;

measuring a third characteristic of light detected by a second sensor of the optical signal detector while the second non-fluorescent surface portion is in the second detection zone of the optical signal detector;

directing light emitted from the optical signal detector into the first void in the second detection zone of the optical signal detector;

measuring a fourth characteristic of light detected by the second sensor of the optical signal detector while the first void is in the second detection zone of the optical signal detector; and

determining the operational performance status of the optical signal detector based on at least one of the third measured characteristic and the fourth measured characteristic.

12. The method of claim 11 , wherein determining the operational performance status of the optical signal detector based on at least one of the third measured characteristic and the fourth measured characteristic comprises determining whether the third measured characteristic is within a second predetermined non-fluorescent-surface characteristic range.

13. The method of claim 11 , wherein each of the first non-fluorescent surface portion and the second non-fluorescent surface portion comprises an aluminum surface.

14. The method of claim 11 , wherein determining the operational performance status of the optical signal detector based on at least one of the third measured characteristic and the fourth measured characteristic comprises determining whether the fourth measured characteristic is within a second predetermined void characteristic range.

15. The method of claim 11 , wherein determining the operational performance status of the optical signal detector based on at least one of the third measured characteristic and the fourth measured characteristic comprises determining the operational performance status of the optical signal detector based on both the third measured characteristic and the fourth measured characteristic.

16. The method of claim 11 , wherein the optical signal detector is a fluorometer.

Assignments (4)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 054089/0804 Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC; GEN-PROBE PRODESSE, INC.
Reel/Frame 075504/0575 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2022
From: OPALSKY, DAVID; RAGHUWANSHI, SRAJAN; BUI, JAMES
To: GEN-PROBE INCORPORATED
Reel/Frame 060060/0721 →
SECURITY INTEREST Recorded Oct 15, 2020
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 054089/0804 →
Continuity (4)
Continuation 16219388 · Dec 13, 2018
Continuation 15389897 · Dec 23, 2016
Provisional Application 62274027 · Dec 31, 2015
Related Publication 20200355610A1 · Nov 12, 2020