Granted Patent B2

US 12,486,348 · App. 16/938,117 · Granted Dec 2, 2025

Inventors: Patricia Martin (Jacksonville, FL); John R. Buch (Jacksonville, FL); Jessica Cannon (Jacksonville, FL); Shivkumar Mahadevan (Jacksonville, FL); Dawn D. Wright (Jacksonville, FL)

Assignee: Johnson & Johnson Vision Care, Inc.

C08F220/1802C09B62/44G02B1/043G02C7/04G02C7/10G02C7/104

Abstract

Claims (32)

1 . A contact lens that is a free radical reaction product of a reactive mixture comprising:

one or more polymerizable compounds suitable for making the contact lens; and

a high energy visible (HEV) light absorbing compound,

wherein the contact lens transmits from 0 percent to 70 percent of light across a wavelength range of 400 to 409 nm,

wherein the contact lens further comprises a UV absorbing compound that is a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile, a salicyclic acid, a benzoic acid, a cinnamic acid, a chalcone, a dypnone, a crotonic acid, or mixtures thereof,

and wherein the contact lens provides a greater reduction in halo size for wearers in a 40 to 65 age group than for wearers in an 18-39 age group, when compared to a control lens that does not contain the HEV light absorbing compound.

2 . The contact lens of claim 1 wherein the contact lens transmits 45 percent or less of light across a wavelength range of 280 to 399 nm.

3 . The contact lens of claim 1 that transmits at least 80 percent of light across a wavelength range of 450 to 800 nm.

4 . The contact lens of claim 1 that is photostable.

5 . The contact lens of claim 1 wherein the high energy visible light absorbing compound is a static compound.

6 . The contact lens of claim 1 wherein the high energy visible light absorbing compound comprises a compound of formula I:

wherein:

m and n are independently 0, 1, 2, 3, or 4;

T is a bond, O, or NR;

Y is a linking group;

P g is a polymerizable group;

R at each occurrence is independently H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—P g ; and

R 1 and R 2 , when present, are independently at each occurrence C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, C 3 -C 7 cycloalkyl, aryl, halo, hydroxy, amino, NR 3 R 4 , or benzyl, wherein R 3 and R 4 are independently H or C 1 -C 6 alkyl, or two adjacent R 1 or R 2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

7 . The contact lens of claim 6 wherein m and n are each independently 0 or 1.

8 . The contact lens of claim 6 wherein Y at each occurrence is independently alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, oxaalkylene, alkylene-amide-alkylene, alkylene-amine-alkylene, or combinations thereof.

9 . The contact lens of claim 6 wherein P g comprises styryl, vinyl carbonate, vinyl ether, vinyl carbamate, N-vinyl lactam, N-vinylamide, (meth)acrylate, or (meth)acrylamide.

10 . The contact lens of claim 1 wherein the UV absorbing compound comprises a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile or mixtures thereof.

11 . The contact lens of claim 1 wherein the polymerizable compound suitable for making the contact lens comprises a hydrophilic component, a silicone-containing component, or mixtures thereof.

12 . A method for improving a vision attribute in a contact lens wearer, the method comprising: providing the contact lens wearer with a contact lens according to claim 1 , wherein the vision attribute is selected from one or more of photostress recovery time, glare discomfort, glare disability threshold, heterochromatic contrast threshold, halo size, starburst size, and light scattering.

13 . A method for improving a vision attribute in a contact lens wearer, the method comprising:

providing the contact lens wearer with a contact lens that is a free radical reaction product of a reactive mixture comprising:

one or more polymerizable compounds suitable for making the contact lens; and

a high energy visible (HEV) light absorbing compound,

a UV absorbing compound that is a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile, a salicyclic acid, a benzoic acid, a cinnamic acid, a chalcone, a dypnone, a crotonic acid, or mixtures thereof,

wherein the contact lens provides a greater reduction in halo size for wearers in a 40 to 65 age group than for wearers in an 18-39 age group, when compared to a control lens that does not contain the HEV light absorbing compound.

14 . The method of claim 12 wherein improving a vision attribute comprises an improvement in the vision attribute as observed by a contact lens wearer when compared to a contact lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm.

15 . The contact lens of claim 1 wherein the HEV light absorbing compound comprises: 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl acrylate; N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)methacrylamide; N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)acrylamide; 2-(2-cyano-N-methyl-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-cyano-2-(9H-thioxanthen-9-ylidene)-N-(2-(N-vinylacetamido)ethyl)acetamide; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)-2-methylpropyl methacrylate; (E)-2-(2-cyano-2-(2,4-dichloro-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; (E)-2-(2-(2-chloro-9H-thioxanthen-9-ylidene)-2-cyanoacetamido)ethyl methacrylate; (E)-2-(2-cyano-2-(2-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; (E)-2-(2-cyano-2-(4-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetoxy)ethyl methacrylate; or mixtures thereof.

Assignments (1)

Continuity (2)

References Cited (363)