Photobleaching method
The present disclosure provides an improved method for photobleaching an eye of a subject. The disclosed method may be used in a number of psychophysical test methods, including, but not limited to, measurement of dark adaptation. The improved method for photobleaching involves at least one of the following improvements: (i) the use of a bleaching light emitting a particular wavelength of light or a tailored spectrum of wavelengths; (ii) restricting or otherwise spatially tailoring the region of the retina that is subject to photobleaching; and (iii) utilizing a bleaching light having an intensity that is at or below the intensity of ambient daylight. The present disclosure additionally provides a combination of a photobleaching light and an apparatus to administer a psychophysical test suitable for use in practicing the disclosed methods.
1. A method for assessing a visual function of a subject's eye, the method comprising:
exposing a portion of rod visual pigments of a restricted region of a retina of the subject's eye to a photobleaching light consisting of wavelengths centered at 560 nm;
exposing a segment of the retina of the subject's eye to a target stimulus light consisting of wavelengths centered at 450 nm, wherein an area of the restricted region is less than 200 times of an area of the segment of the retina exposed to the target stimulus light;
receive a psychophysical response from the subject, the psychophysical response indicating observation of the target stimulus light by the subject; and
assess status of the visual function of the subject's eye based on the psychophysical response.
2. The method of claim 1 , further comprising exposing the restricted region of the retina to the target stimulus light.
3. The method of claim 1 , further comprising determining presence of an eye disease based the status of the visual function.
4. The method of claim 3 , further comprising determining severity of the eye disease based the status of the visual function.
5. The method of claim 3 , wherein the visual function comprises dark adaptation.
6. The method of claim 5 , wherein the eye disease is age-related macular degeneration.
7. The method of claim 3 , wherein the visual function comprises photopic sensitivity.
8. The method of claim 3 , wherein the visual function comprises scotopic sensitivity.
9. The method of claim 3 , wherein the visual function comprises visual acuity.
10. The method of claim 3 , wherein the visual function comprises color sensitivity.
11. The method of claim 3 , wherein the visual function comprises contrast sensitivity.
12. The method of claim 3 , wherein the visual function comprises color discrimination.
13. The method of claim 3 , wherein the visual function comprises visual field.