IP Library Granted Patent US 11,324,943
Granted Patent B2
US 11,324,943 · App. 16/942,953 · Granted May 10, 2022

Devices and methods for vagal nerve stimulation

Inventors: Bruce J. Simon (Mountain Lakes, NJ); Joseph P. Errico (Warren, NJ); John T. Raffle (Austin, TX)
Assignee: ELECTROCORE, INC
A61N1/0456A61N1/0472A61N1/36014A61N1/36034A61N2/006A61N1/36053A61N1/40
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Quick Facts
Patent No.
US 11,324,943
App. No.
16/942,953
Granted
May 10, 2022
Kind
B2
Abstract

Methods and devices for stimulating a nerve in a patient include positioning a device adjacent an outer skin surface of the patient and emitting an electrical field near the vagus nerve within the patient. The electric field is varied to create burst periods and constant periods. The charge of the electric field emitted during the burst periods alternates between positive and negative. The charge of the electric field emitted during the constant periods has a magnitude of zero.

Claims (19)

1. A method for treating a disorder in a patient, the method comprising:

positioning a device adjacent an outer skin surface of the patient;

emitting an electric field near a vagus nerve within the patient; and

varying the electric field to create burst periods and constant periods, wherein the charge of the electric field emitted during the burst periods alternates between positive and negative between 2 and 20 times in each burst period, wherein the frequency of the burst periods is about 15 Hz to about 50 Hz, wherein each burst period has a duration of less than 20,000 microseconds.

2. The method of claim 1 further comprising positioning one or more electrodes near the outer skin surface and applying a voltage to the electrode(s) to generate the electric field.

3. The method of claim 2 further comprising varying the voltage such that the electric field emitted by the electrode includes the burst periods and the constant periods.

4. The method of claim 2 , further comprising transmitting an electric current from the electrode(s) through the outer skin surface to the vagus nerve.

5. The method of claim 1 , wherein the charge of the electric field alternates between positive and negative 4 and 10 times per burst.

6. The method of claim 1 , wherein the electric field emitted during the constant periods has a magnitude of about zero.

7. The method of claim 1 , wherein the constant periods have a longer duration than the burst periods.

8. A device for treating a disorder in a patient, the device comprising:

a housing having a contact surface for contacting an outer skin surface of a patient; and

an energy source coupled to the housing, the energy source being configured to emit an electric field near a vagus nerve within the patient and to vary the electric field to create burst periods and constant periods, wherein the charge of the electric field emitted during the burst periods alternates between positive and negative between 2 and 20 times in each burst period, wherein the frequency of the burst periods is about 15 Hz to about 50 Hz, wherein each burst period has a duration of less than 20,000 microseconds.

9. The device of claim 8 further comprising one or more electrodes coupled to the energy source, wherein the energy source applies a voltage to the electrode(s) to generate the electric field.

10. The device of claim 9 , further comprising varying the voltage such that the electric field emitted by the electrode includes the burst periods and the constant periods.

11. The device of claim 8 , wherein the energy source transmits an electric current through the outer skin surface to the vagus nerve.

12. The device of claim 8 , wherein the charge of the electric field alternates between positive and negative 4 and 10 times per burst.

13. The device of claim 8 , wherein the electric field emitted during the constant periods has a magnitude of about zero.

14. The device of claim 8 , wherein the energy source is housed within the housing.

Assignments (2)
SECURITY INTEREST Recorded Aug 12, 2025
From: ELECTROCORE, INC.
To: AVENUE VENTURE OPPORTUNITIES FUND II, L.P.
Reel/Frame 072452/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2020
From: ELECTROCORE, LLC
To: ELECTROCORE, INC.
Reel/Frame 053360/0200 →
Continuity (9)
Continuation 16520630 · Jul 24, 2019
Division 15149406 · May 9, 2016
Division 14337930 · Jul 22, 2014
Continuation 13075746 · Mar 30, 2011
Continuation In Part 12964050 · Dec 9, 2010
Continuation In Part 12859568 · Aug 19, 2010
Provisional Application 61451259 · Mar 10, 2011
Provisional Application 61415469 · Nov 19, 2010
Related Publication 20200353240A1 · Nov 12, 2020