Anti-inflammatory and senolytic dental care product with tooth whitening characteristics
The present invention relates to the field of dental care, e.g., with toothpaste, tooth gel, mouth-wash, mouth spray or oral care foam. In particular, it provides an anti-inflammatory and senolytic dental care product with tooth whitening characteristics. The dental care product comprises calcium phosphate particles of a specific size, the self-assembling peptide P11-4 or oligopeptide 104 of SEQ ID NO: 1, an extract of a plant of the genus Rhododendron , preferably, an alpine rose or Alpenrose such as Rhododendron ferrugineum or Rhododendron hirsutum , and an extract of a plant of the genus Leontopodium , such as Leontopodium nivale , which is also called Edelweiss. The dental care product may further comprise an extract of a plant of the genus Eleutherococcus , such as Eleutherococcus senticosus , which is also designated Siberian ginseng or Acanthopanax senticosus . In addition to the proven tooth whitening characteristics of said product, which can be a medicinal product or a pharmaceutical composition, it further has a senolytic and anti-inflammatory effect. Thus, the invention provides a method for tooth whitening as well as a method of treating periodontal disease, and/or for eliminating or reducing the number of senescent cells in the gums of a subject. The gums of a subject can thus be rejuvenated, potential loose teeth stabilized, and the well-being increased.
1. Dental care product comprising
a) 0.4-40 wt % calcium phosphate particles having a size of 0.01-50 μm,
b) 0.001-5 wt % of a self-assembling peptide consisting of SEQ ID NO: 1,
c) 0.1-5 wt % of an extract of a plant of the genus Rhododendron , and
d) 0.1-5 wt % of an extract of a plant of the genus Leontopodium.
2. The dental care product of claim 1 , wherein said plant of the genus Rhododendron is Rhododendron ferrugineum or Rhododendron hirsutum.
3. The dental care product of claim 2 , wherein the dental care product comprises 1-2 wt % of an extract of Rhododendron ferrugineum.
4. The dental care product of claim 3 , wherein said plant of the genus Leontododium is Leontopodium nivale.
5. The dental care product of claim 1 , wherein said extract of c) and/or d), optionally, of c) and d), is a glycerinic extract.
6. The dental care product of claim 1 , wherein said extract is an extract of the leaves and/or flowers of the plant of c) and/or d), optionally, of c) and d).
7. The dental care product of claim 1 , wherein said extract is an extract of the flowers of the plant of c) and/or d), optionally, of c) and d).
8. The dental care product of claim 1 , further comprising e) an extract of a plant of the genus Eleutherococcus , optionally, Eleutherococcus senticosus.
9. The dental care product of claim 1 , wherein the self-assembling peptide is in assembled form.
10. The dental care product of claim 1 , wherein said calcium phosphate particles comprise hydroxyapatite.
11. The dental care product of claim 1 , wherein 30-70% of said calcium phosphate particles have a size of 200-600 nm.
12. The dental care product of claim 1 , wherein the dental care product is selected from the group consisting of toothpaste, tooth gel, mouthwash, mouth spray and oral care foam.
13. The dental care product of claim 1 , comprising 0.5-40 wt % of said calcium phosphate particles and 0.02-1 wt % of said self-assembling peptide, wherein the dental care product is a toothpaste.
14. The dental care product of claim 1 , wherein the care dental care product has a senolytic effect when administered to the gums of a subject.
15. The dental care product of claim 1 , wherein the care dental care product has an anti-inflammatory effect when administered to the gums of a subject.
16. A pharmaceutical composition comprising the dental care product of claim 1 .
17. A method of treating periodontal disease or peri-implantitis in a subject, comprising administering an effective amount of the dental care product of claim 1 to the gums of the subject.
18. A method for eliminating or reducing the number of senescent cells in the gums of a subject, comprising administering an effective amount of the dental care product of claim 1 to the gums of the subject.
19. A method for tooth whitening, comprising administering an effective amount of the dental care product of claim 1 to a tooth of a subject.
20. The method of claim 17 , which further is a method of tooth whitening, and of eliminating or reducing the number of senescent cells in the gums of a subject, comprising administering an effective amount of the dental care product of claim 1 to the gums and teeth of a subject.
21. The dental care product of claim 1 , comprising 0.05 wt % of said self-assembling peptide, wherein the dental care product is a toothpaste.
22. The method of claim 19 , wherein the composition is administered one, two or three times a day on 1, 2, 3, 4, 5, 6, 7 or more days.
23. The method of claim 19 , wherein the composition is administered daily.