Adjusting insulin delivery rates
A method may include delivering insulin, using an insulin pump and a controller, over a first diurnal time period based on a baseline basal insulin rate stored in memory. The controller may receive blood glucose data to control delivery of insulin via the insulin pump in amounts variable from the baseline basal insulin rate to control blood glucose levels for a person with diabetes (PWD). The method may also include modifying the baseline basal insulin rate stored in the memory for a second diurnal time period that is at least 20 hours after the first diurnal period based on an amount of insulin actually delivered during the first diurnal time period.
1. A method comprising:
determining to deliver insulin over a first diurnal time period according to a first baseline basal insulin rate of a schedule of baseline basal insulin rates;
based at least partially on received glucose data for a person with diabetes (PWD), delivering insulin during an occurrence of the first diurnal time period in an amount variable from an amount associated with the first baseline basal insulin rate; and
calculating an updated baseline basal insulin rate for a second diurnal time period such that a difference between the updated baseline basal insulin rate and an original, second baseline basal insulin rate associated with the second diurnal time period is less than a difference between the first baseline basal insulin rate stored for the first diurnal time period and a rate at which insulin was actually delivered during the first diurnal time period,
wherein the second diurnal time period is at least 20 hours after the occurrence of the first diurnal time period.
2. The method of claim 1 , further comprising:
removing an association between the original, second baseline basal insulin rate and the second diurnal time period; and
associating the updated baseline basal insulin rate with the second diurnal time period.
3. The method of claim 1 , further comprising waiting to deliver insulin according to the updated baseline basal insulin rate until at least 20 hours after the first diurnal time period.
4. The method of claim 1 , further comprising calculating an updated carbohydrate-to-insulin ratio (CR) for the second diurnal time period based at least partially on the rate at which insulin was actually delivered during the first diurnal time period.
5. The method of claim 1 , further comprising calculating an updated insulin sensitivity factor (ISF) for the second diurnal time period based at least partially on the rate at which insulin was actually delivered during the first diurnal time period.
6. The method of claim 1 , wherein the second diurnal time period is one of a same time period on another day as the first diurnal time period or a time period within two hours prior to the same time period as the first diurnal time period on the another day.
7. The method of claim 1 , wherein the updated baseline basal insulin rate is an increased rate relative to the original, second baseline basal insulin rate if a ratio of the rate at which insulin was actually delivered during the first diurnal time period to the first baseline basal insulin rate for the first diurnal time period exceeds a predetermined first threshold and is a decreased rate relative to the original, second baseline basal insulin rate if the ratio falls below a predetermined second threshold.
8. The method of claim 7 , wherein the updated baseline basal insulin rate is the increased rate or the decreased rate relative to the original, second baseline basal insulin rate by a fixed amount or a percentage that is less than a difference between the rate at which insulin was actually delivered during the first diurnal time period and the first baseline basal insulin rate.
9. The method of claim 8 , wherein the updated baseline basal insulin rate is an increased rate or a decreased rate relative to the original, second baseline basal insulin rate by a percentage between about 1% and about 5% of the original, second baseline basal insulin rate.
10. The method of claim 8 , further comprising calculating an updated CR or an updated ISF for the second diurnal time period, wherein the updated CR or an updated ISF is increased or decreased by a fixed amount or percentage.
11. The method of claim 10 , wherein the updated CR or the updated ISF is increased or decreased relative to an original CR or an original ISF by a percentage between about 1% and about 5%, and wherein the updated baseline basal insulin rate is an increased rate or a decreased rate relative to the original, second baseline basal insulin rate by a percentage between about 1% and about 5%.
12. The method of claim 7 , wherein a difference between the updated baseline basal insulin rate and the original, second baseline basal insulin rate is based at least partially on the ratio, but is less than a difference between the rate at which insulin was actually delivered during the first diurnal time period and the first baseline basal insulin rate.
13. The method of claim 7 , further comprising calculating an updated CR or an updated ISF for the second diurnal time period, wherein the updated CR or an updated ISF is increased when the updated baseline basal insulin rate is less than the original, second baseline basal insulin rate and decreased when the updated baseline basal insulin rate is greater than the original, second baseline basal insulin rate.
14. The method of claim 1 , wherein determining to deliver insulin over the first diurnal time period comprises:
(a) generating a first plurality of basal insulin delivery profiles, each of the first plurality of basal insulin delivery profiles including a first series of insulin delivery actions spanning a first time interval no greater than the first diurnal time period;
(b) calculating a first plurality of future glucose values for each insulin delivery profile of the first plurality of basal insulin delivery profiles for a plurality of times spanning the first time interval, each calculated future glucose value being calculated using at least one up-to-date glucose level for the PWD; and
(c) selecting a first profile of the first plurality of basal insulin delivery profiles based at least in part upon a comparison between the first plurality of future glucose values for each insulin delivery profile and at least one target glucose level.
15. The method of claim 14 , further comprising:
(d) delivering a first dose of insulin for at least part of the first diurnal time period for the first time interval; and
(e) optionally repeating steps (a) through (d) until insulin is delivered for an entire first diurnal time period.
16. The method of claim 14 , wherein each action in the first series of insulin delivery actions includes one of delivering 0, 1, or 2 times the first baseline basal insulin rate.
17. The method of claim 14 , wherein the at least one up-to-date glucose level is determined using an ISF, CR, or combination thereof for the first diurnal time period.
18. The method of claim 1 , furthermore comprising receiving food consumption data.
19. The method of claim 1 , further comprising calculating an additional updated baseline basal insulin rate for a third diurnal time period immediately adjacent to the second diurnal time period to smooth a transition between adjacent diurnal time periods.
20. The method of claim 1 , further comprising delivering insulin during the second diurnal time period according to the updated baseline basal insulin rate.
21. A system comprising:
an insulin pump configured to deliver insulin responsive to a message;
a glucose sensor configured to generate glucose data; and
a controller comprising:
at least one processor; and
at least one non-transitory computer-readable storage medium storing instructions thereon that, when executed by the at least one processor, cause the controller to:
generate instructions to deliver insulin over a first diurnal time period according to a first baseline basal insulin rate of a schedule of baseline basal insulin rates;
during the first diurnal time period, receive glucose data from the glucose sensor;
based at least partially on the received glucose data, generate instructions to deliver insulin during an occurrence of the first diurnal time period in an amount variable from an amount associated with the first baseline basal insulin rate; and
calculate an updated baseline basal insulin rate for a second diurnal time period such that a difference between the updated baseline basal insulin rate and an original, second baseline basal insulin rate associated with the second diurnal time period is less than a difference between the first baseline basal insulin rate stored for the first diurnal time period and a rate at which insulin was actually delivered during the first diurnal time period,
wherein the second diurnal time period is at least 20 hours after the occurrence of the first diurnal time period.
22. The system of claim 21 , further comprising instructions that, when executed by the at least one processor, cause the controller to:
remove an association between the original, second baseline basal insulin rate and the second diurnal time period; and
associate the updated baseline basal insulin rate with the second diurnal time period.
23. The system of claim 21 , further comprising instructions that, when executed by the at least one processor, cause the controller to wait to deliver insulin according to the updated baseline basal insulin rate until at least 20 hours after the first diurnal time period.
24. The system of claim 21 , wherein the controller comprises part of the insulin pump.
25. The system of claim 21 , wherein the controller comprises a device separate from the insulin pump.
26. A system comprising:
an insulin pump configured to deliver insulin responsive to a message;
a glucose sensor configured to generate glucose data; and
a controller comprising:
at least one processor; and
at least one non-transitory computer-readable storage medium storing instructions thereon that, when executed by the at least one processor, cause the controller to:
generate instructions to deliver insulin over a first diurnal time period according to a first baseline basal insulin rate of a schedule of baseline basal insulin rates;
during the first diurnal time period, receive glucose data from the glucose sensor;
based at least partially on the received glucose data, generate instructions to deliver insulin during an occurrence of the first diurnal time period in an amount variable from an amount associated with the first baseline basal insulin rate; and
calculate an updated baseline basal insulin rate for a second diurnal time period such that a difference between the updated baseline basal insulin rate and an original, second baseline basal insulin rate associated with the second diurnal time period is less than a difference between the first baseline basal insulin rate stored for the first diurnal time period and a rate at which insulin was actually delivered during the first diurnal time period,
wherein the second diurnal time period is at least 20 hours after the occurrence of the first diurnal time period.