IP Library Granted Patent US 11,938,214
Granted Patent B2
US 11,938,214 · App. 16/952,433 · Granted Mar 26, 2024

Benefit agent delivery system comprising microcells having an electrically eroding sealing layer

Inventor: Lei Liu (Fremont, CA)
Assignee: E INK CORPORATION
A61K9/0009A61K9/703A61M37/00A61M2037/0007A61M2205/0216A61M2205/0233A61M2205/0238A61M2207/10
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Quick Facts
Patent No.
US 11,938,214
App. No.
16/952,433
Granted
Mar 26, 2024
Kind
B2
Abstract

A benefit agent delivery system whereby benefit agents can be delivered on demand and/or a variety of different benefit agents at different concentrations can be delivered from the same system. The benefit agent delivery system includes a microcell layer comprising a plurality of microcells, wherein the microcells are filled with a carrier and a benefit agent. The microcells include an opening, wherein the opening is spanned by a sealing layer comprising a polymer and metallic material. Application of an electric field across the microcell layer and the sealing layer results in the migration of the metallic material from the sealing layer and the creation of a porous sealing layer, allowing the benefit agent to be released from the benefit agent delivery system.

Claims (24)

1. A benefit agent delivery system comprising:

a conductive layer;

a microcell layer comprising a plurality of microcells, wherein each microcell includes an opening, and wherein a medium comprising a carrier and a benefit agent is contained in the plurality of microcells;

a sealing layer spanning the opening of each microcell and comprising a polymeric material and a metallic material;

an electrode layer, and

a voltage source that is coupled to the conductive layer and the electrode layer;

wherein the conductive layer, the microcell layer, the sealing layer and the electrode layer are vertically stacked upon each other;

wherein the microcell layer and the sealing layer are disposed between the conductive layer and the electrode layer, and

wherein, when a voltage is applied from the voltage source between the conductive layer and the electrode layer, the metallic material is oxidized and removed from the sealing layer, creating a porous sealing layer.

2. The benefit agent delivery system of claim 1 , wherein the conductive layer, the microcell layer, the sealing layer and the electrode layer are vertically stacked upon each other in this order, and wherein the electrode layer is porous.

3. The benefit agent delivery system of claim 1 , wherein the polymeric material of the sealing layer is selected from the group consisting of an acrylate, a methacrylate, a polycarbonate, a polyvinyl alcohol, cellulose, poly(N-isopropylacrylamide) (PNIPAAm), poly(lactic-co-glycolic acid) (PLGA), polyvinylidene chloride, acrylonitrile, amorphous nylon, oriented polyester, terephthalate, polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyurethane, and alginate.

4. The benefit agent delivery system of claim 1 , wherein the metallic material of the sealing layer is selected from the group consisting of metal particles, metal wires, metal fibers, metal flakes, metal rods, metal aggregates, and metal disks.

5. The benefit agent delivery system of claim 1 , wherein the metallic material of the sealing layer comprises silver, copper, gold, platinum, zinc, chromium, nickel or combination thereof.

6. The benefit agent delivery system of claim 1 , wherein the sealing layer further comprises a conductive material selected from the groups consisting of carbon black, carbon nanotubes, graphene, a dopant, and a conductive polymer.

7. The benefit agent delivery system of claim 1 , wherein the carrier is selected from the group consisting of a liquid, a semi-solid, a gel and combinations thereof.

8. The benefit agent delivery system of claim 1 , wherein the carrier is selected from a group comprising water, an organic compound, a silicone compound, and a combination thereof.

9. The benefit agent delivery system of claim 1 , wherein the plurality of microcells comprises a benefit agent selected from the group consisting of a pharmaceutical agent, a vaccine, an antibody, a hormone, a protein, a nucleic acid, a nutraceutical agent, a nutrient, a cosmetic agent, a fragrance, a malodor removing agent, an agricultural agent, an air care agent, an anti-microbial agent, and a preservative.

10. The benefit agent delivery system of claim 1 , wherein the sealing layer further comprises a benefit agent.

11. The benefit agent delivery system of claim 2 , wherein the sealing layer and the electrode layer are integrated into one layer.

12. The benefit agent delivery system of claim 2 , further comprising a porous diffusion layer or a rate control layer between the sealing layer and the electrode layer.

13. The benefit agent delivery system of claim 12 , wherein the electrode layer and the porous diffusion layer are integrated into one layer.

14. The benefit agent delivery system of claim 2 , further comprising an adhesive layer disposed between the sealing layer and the electrode layer.

15. The benefit agent delivery system of claim 14 , further comprising a porous diffusion layer disposed between the adhesive layer and the electrode layer.

16. The benefit agent delivery system of claim 15 , wherein the porous diffusion layer and the adhesive layer are integrated in one layer, and wherein the integrated layer has volume resistivity of less than 10 −10 Ohm*cm.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2023
From: E INK CALIFORNIA, LLC
To: E INK CORPORATION
Reel/Frame 065123/0578 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 11, 2021
From: LIU, LEI
To: E INK CALIFORNIA, LLC
Reel/Frame 054874/0608 →
Continuity (2)
Provisional Application 62941216 · Nov 27, 2019
Related Publication 20210154133A1 · May 27, 2021