A VACCINE TO PROTECT A PIG AGAINST ACTINOBACILLUS PLEUROPNEUMONIAE
The present invention pertains to a vaccine to protect a pig against an infection with Actinobacillus pleuropneumoniae , the vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus, and a pharmaceutically acceptable carrier.
1 . A vaccine to protect a pig against an infection with Actinobacillus pleuropneumoniae , the vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus, and a pharmaceutically acceptable carrier.
2 . The vaccine of claim 1 , wherein the RTX toxin is ApxI.
3 - 6 . (canceled)
7 . A method of protecting a pig against an infection with Actinobacillus pleuropneumoniae , by administering a vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus and a pharmaceutically acceptable carrier, to the pig.
8 . The method of claim 7 , wherein the RTX toxin is ApxI.
9 . The method of claim 8 , wherein the vaccine is administered systemically.
10 . The method of claim 8 , wherein the vaccine is administered intramuscularly
11 . The method of claim 8 , wherein the vaccine is administered intradermally.
12 . The method of claim 7 , wherein the vaccine is administered systemically.
13 . The method of claim 7 , wherein the vaccine is administered intramuscularly
14 . The method of claim 7 , wherein the vaccine is administered intradermally.