Biomedical foam

1. A foam nasal dressing for topically administering a drug to a nasal cavity and for absorbing fluid discharge, the nasal dressing comprising:

a foamed core portion comprising a first polyurethane, the foamed core portion including amorphous segments and crystalline segments, and a hemostatic agent;

a foamed shell portion arranged such that the foamed core portion is disposed within the foamed shell portion, the foamed shell portion having a porosity of greater than 80% and comprising a second polyurethane, the foamed shell portion including amorphous segments and crystalline segments, wherein the first and second polyurethanes are the same or different;

a drug disposed in the foamed shell portion;

the nasal dressing having an elongate shape extending from a first end to a second end, the nasal dressing having a first half adjacent the first end and a second half adjacent the second end; and

a foamed base portion at the second end with the foamed shell portion and the foamed core portion extending from the foamed base portion towards the first end, such that the foamed base portion and the foamed shell portion cooperate to encapsulate the foamed core portion and define an outer surface of the nasal dressing;

wherein a weight of the drug in the first half of the foam nasal dressing is greater than a weight of the drug in the second half of the foam nasal dressing; and wherein the foamed base portion comprises the first polyurethane and is integral with the foamed core portion.

2. The foam nasal dressing as set forth in claim 1 , wherein the drug comprises a steroid, and wherein the foamed shell portion includes the steroid, and the foamed core portion is substantially free of the steroid.

3. The foam nasal dressing as set forth in claim 2 , wherein the steroid includes at least one hydrogen atom which is bound to a nitrogen, oxygen, or fluorine atom.

4. The foam nasal dressing as set forth in claim 1 , wherein the foamed shell portion and the foamed core portion are bonded to one another via hydrogen bonding and substantially free of covalent bonds therebetween.

5. The foam nasal dressing as set forth in claim 1 , wherein:

the crystalline segments in the first and/or the second polyurethane comprise the reaction product of 1,4 butanediol and 1,4 diisocyanatobutane; and/or

wherein molecules within the first and/or second polyurethane foam are arranged so that the crystalline segments and the amorphous segments stack in an alternating configuration to provide a 3-dimensional porous structure which is strengthened via hydrogen bonding between the stacked crystalline segments.

6. The foam nasal dressing as set forth in claim 1 , wherein the foamed core portion includes the drug at a first concentration, and the foamed shell portion includes a second drug, which is the same as or different than the drug, at a second concentration.

7. The foam nasal dressing as set forth in claim 1 , wherein the foamed core portion and/or the foamed shell portion comprise a hemostatic agent.

8. The foam nasal dressing as set forth in claim 7 , wherein the hemostatic agent includes at least one hydrogen atom bonded to a nitrogen atom, and at least one hydrogen atom bonded to an oxygen atom.

9. The foam nasal dressing as set forth in claim 8 , wherein molecules of the hemostatic agent and molecules of the second polyurethane foam are bonded to one another via hydrogen bonding and substantially free of covalent bonds therebetween.

10. The foam nasal dressing as set forth in claim 7 , wherein the hemostatic agent is insoluble in the first and/or second polyurethane foam and the drug is a steroid that is insoluble in the first and/or second polyurethane foam.

11. The foam nasal dressing as set forth in claim 1 , wherein the foam dressing is free from any lumen.

12. The foam nasal dressing as set forth in claim 1 , wherein a volume of the foamed shell portion is from about 20 to about 40% of a total volume of the foam nasal dressing and/or wherein the foamed core portion has a porosity of greater than 80%.

13. The foam nasal dressing as set forth in claim 1 , wherein:

the foamed core portion is completely disposed within the foamed shell portion;

the foamed core portion is cylindrically-shaped; and/or

a cross-section of the foamed shell portion has a square or rectangular shape and is the same shape as a cross-section of the foamed base portion.