Absorbable metal stent

1. An absorbable metal stent, comprising an absorbable metal substrate, wherein the absorbable metal substrate comprises a plurality of wave-shaped annular structures and a plurality of axial connecting portions, two ends of each axial connecting portion being connected to two adjacent wave-shaped annular structures respectively so as to axially connect the plurality of wave-shaped annular structures; a corrosion-promoting coating is formed on each axial connecting portion, the corrosion-promoting coating containing a corrosion-promoting substance, and the corrosion-promoting substance being selected from at least one of a degradable polymer and a degradable polymer antioxidant; and the corrosion-promoting coatings make the corrosion of the axial connecting portions to occur earlier than the corrosion of the plurality of wave-shaped annular structures; wherein the absorbable metal stent further comprises a first corrosion inhibition layer, and the first corrosion inhibition layer is formed on each of the wave-shaped annular structures;

wherein the absorbable metal stent is configured to preferentially be axially deconstructed in sequence after implantation of the absorbable metal stent to form a plurality of independent wave-shaped annular structures;

wherein the absorbable metal stent further comprises a degradable polymer layer provided on each of the wave-shaped annular structures, and

wherein the degradable polymer in the degradable polymer layers and the corrosion-promoting substance in the corrosion-promoting coatings are formed from the same structural units, and a polydispersity coefficient of the corrosion-promoting substance in the corrosion-promoting coatings is greater than a polydispersity coefficient of the degradable polymer in the degradable polymer layers.

2. The absorbable metal stent according to claim 1 , wherein the degradable polymer is selected from at least one of a degradable polyester, a degradable polyanhydride, and a degradable polyamino acid; and a chain segment or monomer released when the degradable polymer antioxidant is degraded includes at least one of ascorbic acid, glutathione, lipoic acid, and proanthocyanidin.

3. The absorbable metal stent according to claim 1 , wherein a second corrosion inhibition layer is formed on each of the axial connecting portions, the corrosion-promoting coating at least partially covers the second corrosion inhibition layer, and the thickness of the first corrosion inhibition layer is greater than or equal to the thickness of the second corrosion inhibition layer.

4. The absorbable metal stent according to claim 1 , wherein each of the wave-shaped annular structures comprises a plurality of wave peaks, a plurality of wave troughs, and a plurality of support rods; two ends of each of the support rods are respectively connected to one of the wave peaks and one of the wave troughs, which are adjacent to each other, to form the wave-shaped annular structure; each first corrosion inhibition layer is a coating having a non-uniform thickness, and the thicknesses of portions of the first corrosion inhibition layer located at the wave peak and the wave trough are less than or equal to the thickness of the first corrosion inhibition layer located at the support rod, respectively.

5. The absorbable metal stent according to claim 1 , wherein the absorbable metal substrate is an iron substrate, an iron-based alloy substrate, a magnesium substrate, a magnesium-based alloy substrate, a zinc substrate or a zinc-based alloy substrate.

6. The absorbable metal stent according to claim 1 , wherein the wave-shaped annular structures are made of iron or an iron-based alloy, and the axial connecting portions are made of a magnesium alloy.

7. The absorbable metal stent according to claim 2 , wherein the material of the degradable polymer layer is selected from at least one of a degradable polyester, a degradable polyanhydride, and a degradable polyamino acid.

8. The absorbable metal stent according to claim 7 , wherein the thickness of each degradable polymer layer is less than or equal to the thickness of each corrosion-promoting coating.

9. The absorbable metal stent according to claim 7 , wherein a molecular weight of the degradable polymer in the corrosion-promoting coatings is less than or equal to a molecular weight of the degradable polymer in the degradable polymer layers.

10. The absorbable metal stent according to claim 7 , wherein each of the wave-shaped annular structures comprises a plurality of wave peaks, a plurality of wave troughs, and a plurality of support rods; two ends of each of the support rods are respectively connected to one of the wave peaks and one of the wave troughs, which are adjacent to each other, to form the wave-shaped annular structure; the degradable polymer layer is a coating having a non-uniform thickness, and the thicknesses of portions of the degradable polymer layer located at the wave peak and the wave trough are greater than or equal to the thickness of the degradable polymer layer located at the support rod, respectively.

11. The absorbable metal stent according to claim 7 , wherein each of the wave-shaped annular structures comprises a plurality of wave peaks, a plurality of wave troughs, and a plurality of support rods; two ends of each of the support rods are respectively connected to one of the wave peaks and one of the wave troughs, which are adjacent to each other, to form the wave-shaped annular structure; and a molecular weight of the degradable polymer in portions of the degradable polymer layer located at the wave peak and the wave trough is less than or equal to a molecular weight of the degradable polymer in the degradable polymer layer located at the support rod.

12. The absorbable metal stent according to claim 7 , wherein each of the wave-shaped annular structures comprises a plurality of wave peaks, a plurality of wave troughs, and a plurality of support rods; two ends of each of the support rods are respectively connected to one of the wave peaks and one of the wave troughs, which are adjacent to each other, to form the wave-shaped annular structure; and polydispersity coefficients of the degradable polymer in portions of the degradable polymer layer located at the wave peak and the wave trough are greater than or equal to a polydispersity coefficient of the degradable polymer in the degradable polymer layer located at the support rod.

13. The absorbable metal stent according to claim 2 , wherein the degradable polyester is selected from at least one of the group consisting of polylactic acid, polyglycolic acid, polycaprolactone, polysuccinate, poly(β-hydroxybutyrate), polyethyl dialcohol adipate, and polyhydroxybutyrate valerate, or the degradable polyester is selected from a copolymer formed by copolymerizing at least two kinds of monomers forming polylactic acid, polyglycolic acid, polycaprolactone, polysuccinate, poly(β-hydroxybutyrate), polyethyl dialcohol adipate, and polyhydroxybutyrate valerate.

14. The absorbable metal stent according to claim 2 , wherein the degradable polyanhydride is selected from at least one of the group consisting of polyoxalic anhydride, polybutanedioic anhydride, polyadipic anhydride, polysebacic anhydride, polydodecanoic anhydride, polycitric anhydride, polymalic anhydride, polysuccinic anhydride, polytartaric anhydride, polyitaconic anhydride, and polymaleic anhydride; or the degradable polyanhydride is a copolymer formed by copolymerizing at least one of monomers forming polyoxalic anhydride, polybutanedioic anhydride, polyadipic anhydride, polysebacic anhydride, polydodecanoic anhydride, polycitric anhydride, polymalic anhydride, polysuccinic anhydride, polytartaric anhydride, polyitaconic anhydride and polymaleic anhydride, and at least one of monomers forming polylactic acid, polyglycolic acid, polycaprolactone, polysuccinate, poly(β-hydroxybutyrate), polyethyl dialcohol adipate, and polyhydroxybutyrate valerate.

15. The absorbable metal stent according to claim 2 , wherein the monomer that forms the degradable polyamino acid is selected from at least one of monomers forming polylysine, polyaspartic acid, polycysteine, polymethionine, polyornithine, polyglycine, and polyglutamic acid.

16. The absorbable metal stent according to claim 7 , wherein the anti-corrosion coating and/or the degradable polymer layer contains an active drug, the active drug being selected from at least one of the group consisting of a drug that inhibits vascular proliferation, an antiplatelet drug, an antithrombotic drug, an anti-inflammatory drug and an anti-allergenic drug.

17. The absorbable metal stent according to claim 16 , wherein the drug that inhibits vascular proliferation is selected from at least one of paclitaxel, rapamycin and derivatives thereof; the anti-platelet drug is cilostazol; the antithrombotic drug is heparin; the anti-inflammatory drug is dexamethasone; and the anti-allergenic drug is selected from at least one of calcium gluconate, chlorpheniramine and cortisone.

18. The absorbable metal stent according to claim 1 , wherein the first corrosion inhibition layer is only formed on each of the wave shaped annular structures.

19. The absorbable metal stent according to claim 1 , wherein the corrosion-promoting coating is only formed on each axial connecting portion.