IP Library › Granted Patent US 11,891,378
Granted Patent B2
US 11,891,378 · App. 16/958,022 · Granted Feb 6, 2024

Small molecule modulators of pantothenate kinases

Inventors: Richard E. Lee (Cordova, TN); Rajendra P. Tangallapally (Collierville, TN); Charles O. Rock (Bartlett, TN); Suzanne Jackowski (Bartlett, TN); Anne V. Edwards (Memphis, TN); Mi Kyung Yun (Collierville, TN); Chitra Subramanian (Cordova, TN); Robert Zamboni (Beaconsfield, CA); T. Jagadeeswar Reddy (Pierrefonds, CA)
Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.; COA THERAPEUTICS, INC.
C07D403/04A61K31/197
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Quick Facts
Patent No.
US 11,891,378
App. No.
16/958,022
Granted
Feb 6, 2024
Kind
B2
Abstract

The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claims (5)

1. A compound, represented by the formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition, comprising a compound, represented by the formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

3. The pharmaceutical composition of claim 2 , in an oral dosage form.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 8, 2025
From: COA THERAPEUTICS, INC.
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Reel/Frame 071065/0586 →
RELEASE OF SECURITY INTEREST IN PATENT COLLATERAL Recorded Mar 5, 2025
From: BLUE OWL CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
To: BRIDGEBIO PHARMA, INC.; QED THERAPEUTICS, INC.; EIDOS THERAPEUTICS, INC.; ML BIO SOLUTIONS INC.; CALCILYTIX THERAPEUTICS INC.; ADRENAS THERAPEUTICS INC.; PHOENIX TISSUE REPAIR, INC.; NAVIRE PHARMA, INC.; VENTHERA, INC.; MOLECULAR SKIN THERAPEUTICS, INC.; CANTERO THERAPEUTICS, INC.; COA THERAPEUTICS, INC.; PORTAL THERAPEUTICS, INC.; BRIDGEBIO GENE THERAPY RESEARCH, INC.; FERRO THERAPEUTICS, INC.
Reel/Frame 070551/0095 →
SECURITY INTEREST Recorded Jan 19, 2024
From: BRIDGEBIO PHARMA, INC.; QED THERAPEUTICS, INC.; EIDOS THERAPEUTICS, INC.; THERAS, INC.; ML BIO SOLUTIONS INC.; CALCILYTIX THERAPEUTICS INC.; ADRENAS THERAPEUTICS INC.; PHOENIX TISSUE REPAIR, INC.; NAVIRE PHARMA, INC.; VENTHERA, INC.; MOLECULAR SKIN THERAPEUTICS, INC.; CANTERO THERAPEUTICS, INC.; COA THERAPEUTICS, INC.; PORTAL THERAPEUTICS, INC.; BRIDGEBIO GENE THERAPY RESEARCH, INC.; FERRO THERAPEUTICS, INC.; SUB21, INC.
To: BLUE OWL CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 066355/0126 →
SECURITY INTEREST Recorded Jan 17, 2024
From: CALCILYTIX THERAPEUTICS INC.; ADRENAS THERAPEUTICS INC.; PHOENIX TISSUE REPAIR, INC.; NAVIRE PHARMA, INC.; VENTHERA, INC.; MOLECULAR SKIN THERAPEUTICS, INC.; CANTERO THERAPEUTICS, INC.; COA THERAPEUTICS, INC.; PORTAL THERAPEUTICS, INC.; BRIDGEBIO GENE THERAPY RESEARCH, INC.; FERRO THERAPEUTICS, INC.; SUB21, INC.
To: BLUE OWL CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 066342/0154 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2020
From: LEE, RICHARD E.; TANGALLAPALLY, RAJENDRA P.; ROCK, CHARLES O.; JACKOWSKI, SUZANNE; EDWARDS, ANNE V.; YUN, MI KYUNG; SUBRAMANIAN, CHITRA
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Reel/Frame 053992/0074 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2020
From: ZAMBONI, ROBERT; REDDY, T. JAGADEESWAR
To: COA THERAPEUTICS, INC.
Reel/Frame 053993/0104 →
Cited By (2)
US 12,545,663 US 12,552,765