FRAMELESS ULTRASOUND THERAPY
Various approaches to creating a treatment plan for a target include using the first imaging modality to acquire one or more images of the target during a time interval and based thereon determining information associated with the target; also during the time interval, using the second imaging modality having a higher rate of image capture than the first imaging modality to acquire a series of images of the first imageable object that has a relative location with respect to the target; in real time during the time interval, tracking movement of the anatomical target based on the one or more images thereof, the series of images of the first imageable object and the relative location of the first imageable object with respect to the target; and based at least in part on the tracked movement and the information associated with the anatomical target during the time interval, generating a treatment plan for treating the target.
1 . A system for treating an anatomical target, the system comprising:
(a) a treatment apparatus;
(b) a first imaging modality for acquiring one or more images of the anatomical target during a time interval;
(c) a second imaging modality for acquiring a series of images of a first imageable object during the time interval, wherein the first imageable object has a relative location with respect to the anatomical target and the second imaging modality has a higher rate of image capture than the first imaging modality; and
(d) a controller configured to (i) process the one or more images of the anatomical target so as to determine information associated with the target, (ii) process the series of images of the first imageable object, (iii) track movement of the anatomical target based on the series of images and the relative location of the first imageable object with respect to the anatomical target, and (iv) based at least in part on the tracked movement and the information associated with the anatomical target during the time interval, generate a treatment plan associated with the treatment apparatus for treating the anatomical target.
2 . The system of claim 1 , wherein the controller is further configured to activate the treatment apparatus based at least in part on the treatment plan.
3 . The system of claim 1 , wherein the first or second imaging modality is further configured acquire a second series of images of a second imageable object, and the controller is further configured to track movement of the anatomical target based at least in part on the second series of images of the second imageable object.
4 . The system of claim 1 , further comprising a third imaging modality for acquiring a second series of images of a second imageable object, the controller being further configured to track movement of the anatomical target based at least in part on the second series of images of the second imageable object.
5 . The system of claim 1 , wherein the controller is further configured to track movement of the anatomical target based at least in part on a predicted movement of the anatomical target.
6 . The system of claim 1 , wherein the controller is further configured to track movement of the anatomical target based at least in part on a predicted movement of a second imageable object.
7 . The system of claim 1 , wherein the first imageable object comprises the anatomical target.
8 . The system of claim 1 , wherein the first imageable object is different from the anatomical target, and the controller is further configured to determine the location of the first imageable object in each of the series of images acquired in step (c), and infer a location of the anatomical target based on the determined location of the first imageable object.
9 . The system of claim 8 , wherein the first imageable object is an anatomical feature.
10 . The system of claim 8 , wherein the first imageable object is an MR tracker.
11 . The system of claim 1 , wherein the information associated with the anatomical target comprises at least one of a location, a thermal map, a microbubble dose map, or a temporal cavitation activity map thereof.
12 . The system of claim 1 , wherein the controller is further configured to update the information associated with the anatomical target based on the tracked movement thereof.
13 . The system of claim 12 , wherein the one or more images of the anatomical target comprise one or more baseline phase images, and the controller is further configured to subtract a phase shift associated with the tracked movement from the one or more baseline phase images so as to generate a thermal map of the anatomical target.
14 . The system of claim 13 , wherein the first imaging modality further acquires a reference library comprising a series of reference images of the first imageable object.
15 . The system of claim 14 , wherein the controller is further configured to (i) compare one of the images of the first imageable object acquired using the second imaging modality against the reference images in the reference library to identify a best-matching reference image and (ii) determine the phase shift based at least in part on the identified best-matching reference image.
16 . The system of claim 1 , wherein the first and the second imaging modality comprise an MRI apparatus, wherein the MRI apparatus is configured to acquire the one or more images of the anatomical target at a relatively slower scanning rate and to acquire the series of images of the first imageable object at a relatively faster scanning rate.
17 . The system of claim 1 , wherein the first imaging modality comprises an MRI apparatus and the second imaging modality comprises a camera.
18 . The system of claim 1 , wherein the first imaging modality comprises an MRI apparatus and the second imaging modality comprises an ultrasound apparatus.
19 . The system of claim 18 , wherein the treatment apparatus comprises the ultrasound apparatus.
20 . The system of claim 18 , wherein the treatment apparatus comprises a second ultrasound apparatus different from the second imaging modality.
21 . The system of claim 18 , wherein the ultrasound apparatus comprises a plurality of transducer elements, and the treatment plan specifies at least one of an amplitude, a frequency, a phase, a direction or an activation time associated with at least one of the transducer elements.
22 - 95 . (canceled)