Engineered proteins and methods of use
Provided herein are proteins that include at least one B cell domain and at least one T cell domain. Also provided are compositions that include one or more of the proteins and methods for using the proteins.
1. A non-natural protein comprising an amino acid sequence having at least 80% sequence identity to the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6.
2. A non-natural protein comprising an amino acid sequence having at least 80% sequence identity to the amino acid sequence of SEQ ID NO:3 or SEQ ID NO:4.
3. The protein of claim 2 wherein the protein further comprises two or more copies of the amino acid sequence, wherein the two or more copies are present as a tandem repeat.
4. The protein of claim 2 wherein the protein comprises at least three copies of the amino acid sequence, wherein the three or more copies are present as a tandem repeat.
5. A non-natural protein comprising amino acids 7-518 of the amino acid sequence of SEQ ID NO:8 or amino acids 7-365 of the amino acid sequence of SEQ ID NO:10.
6. A composition comprising the protein of claim 1 .
7. The composition of claim 6 further comprising a pharmaceutically acceptable carrier.
8. The composition of claim 6 further comprising an adjuvant.
9. A composition comprising the protein of claim 2 .
10. The composition of claim 9 further comprising a pharmaceutically acceptable carrier.
11. The composition of claim 9 further comprising an adjuvant.