Methods and systems for nerve conduction block
Disclosed herein are systems and methods for nerve conduction block that can involve the delivery of relatively high amounts of charge safely to tissue. Such systems and methods can include control systems for safely monitoring a direct current electrode system, including delivering direct current via an electrode lead to a target tissue of a patient; measuring the driving voltage across the electrode; comparing the driving voltage across the electrode to predetermined threshold range values; measuring the body impedance; determining a voltage drop across the lead from the body impedance measurement; and adjusting the driving voltage to maintain the voltage drop across the lead within a predetermined voltage range.
1. A method for conditioning a working electrode, comprising:
delivering direct current of a first polarity over a first duration to a working electrode;
delivering direct current of a second polarity opposite the first polarity over a second duration to the working electrode;
determining a magnitude of a peak voltage having the first polarity over the first duration;
determining a magnitude of a peak voltage having the second polarity over the second duration;
determining that the magnitude of the peak voltage having the first polarity and the magnitude of the peak voltage having the second polarity are below a peak voltage absolute threshold limit; and
increasing a current magnitude of the direct current of the first polarity and second polarity by an amount such that the increased current magnitude of the direct current of the first polarity and second polarity remains below a pre-determined current limit.
2. The method of claim 1 , wherein the amount is a pre-determined amount.
3. The method of claim 1 , wherein the first polarity is anodic and the second polarity is cathodic.
4. The method of claim 1 , wherein the pre-determined current limit is 5 mA.
5. The method of claim 1 , wherein the peak voltage absolute threshold limit is 1.5V.
6. The method of claim 1 , further comprising:
delivering to the working electrode direct current having the increased current magnitude and of the first polarity over the first duration;
delivering to the working electrode direct current having the increased current magnitude and of the second polarity over the second duration;
determining an updated magnitude of the peak voltage having the first polarity over the first duration;
determining an updated magnitude of the peak voltage having the second polarity over the second duration;
determining that the updated magnitude of the peak voltage having the first polarity or the updated magnitude of the peak voltage having the second polarity are above the absolute threshold limit; and
decreasing the increased current magnitude by a pre-determined amount.
7. The method of claim 1 , wherein one cycle of direct current delivery comprises delivering direct current of the first polarity over the first duration and delivering direct current of the second polarity opposite the first polarity over the second duration comprises a cycle of direct current delivery, and wherein the method further comprises delivering at least 10 cycles of direct current delivery.
8. The method of claim 1 , wherein the working electrode comprises silver chloride.