A DBAIT MOLECULE AGAINST ACQUIRED RESISTANCE IN THE TREATMENT OF CANCER
The invention relates to a method for delaying and/or preventing development of cancer resistant to a cancer therapy agent in a patient based on administration of a Dbait molecule.
1 - 15 . (canceled)
16 . A method for delaying development of cancer resistant to a cancer therapy agent in a patient having cancer comprising administering an effective amount of a Dbait molecule and, optionally, a second cancer therapy agent to the patient, thereby delaying development of cancer resistant to a cancer therapy agent.
17 . The method according to claim 16 , wherein the cancer therapy agent is a Dbait molecule.
18 . The method according to claim 16 , wherein the second cancer therapy agent is a chemotherapy or a targeted therapy.
19 . The method according to claim 16 , wherein the second cancer therapy agent is a PARP inhibitor.
20 . The method according to claim 19 , wherein the PARP inhibitor is selected from the group consisting of olaparib, rucaparib, niraparib, talazoparib, iniparib and veliparib.
21 . The method according to claim 16 , wherein the second cancer therapy agent is selected from the group consisting of a platinum agent, an alkylating agent, a camptothecin, a nitrogen mustard, an antibiotic, an antimetabolite, and a vinca.
22 . The method according to claim 21 , wherein the second cancer therapy agent is a platinum agent.
23 . The method according to claim 16 , wherein the Dbait molecule is administered in at least two cycles.
24 . The method according to claim 16 , wherein the Dbait molecule is to be administered in combination therapy with the second cancer therapy agent.
25 . The method according to claim 23 , wherein the Dbait molecule and the second cancer therapy agent are administered in at least two cycles.
26 . The method according to claim 25 , wherein the Dbait molecule and the second cancer therapy agent are administered in combination for at least three or four cycles.
27 . The method according to claim 16 , wherein the Dbait molecule has one of the following formulae:
wherein N is a deoxynucleotide, n is an integer from 1 to 195, the underlined N refers to a nucleotide having or not a modified phosphodiester backbone, L′ is a linker, C is the molecule facilitating endocytosis selected from a lipophilic molecule or a ligand which targets cell receptor enabling receptor mediated endocytosis, L is a linker, m and p, independently, are an integer being 0 or 1.
28 . The method according to claim 27 , wherein the Dbait molecule has the following formula:
with the same definition than formulae (I), (II), and (III) for N, N, n, L, L′, C and m.
29 . The method according to claim 27 , wherein the Dbait molecule has the following formula:
30 . The method according to claim 16 , wherein the cancer is selected from the group consisting of leukemia, lymphoma, sarcoma, melanoma, and cancers of the head and neck, kidney, ovary, pancreas, prostate, thyroid, lung, esophagus, breast, bladder, brain, colorectum, liver and cervix.
31 . The method according to claim 22 , wherein the platinum agent is selected from the group consisting of cisplatin, oxaliplatin and carboplatin.