IP Library Granted Patent US 11,358,931
Granted Patent B2
US 11,358,931 · App. 16/983,617 · Granted Jun 14, 2022

Selective androgen receptor modulators (SARMs) and uses thereof

Inventor: Lin Zhi (San Diego, CA)
Assignee: Ligand Pharmaceuticals Incorporated
C07D207/09A61K31/401A61K31/402A61K31/5383A61K45/06A61P5/28C07D207/08C07D207/16C07D498/04Y02A50/30
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Quick Facts
Patent No.
US 11,358,931
App. No.
16/983,617
Granted
Jun 14, 2022
Kind
B2
Abstract

Provided herein are compounds, such as compounds of Formula I, that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

Claims (5)

1. A compound of Formula I:

wherein: R 1 is CF 3 ; R 2 is H and R 3 is H; or a pharmaceutically acceptable salt thereof.

2. R,R-4-(2-(1-Hydroxyl-2,2,2-trifluoroethyl)-pyrrolidinyl)-2-trifluoromethyl-benzonitrile.

3. A pharmaceutical composition comprising an effective amount of the compound of claim 1 ; and a pharmaceutical acceptable carrier.

4. A pharmaceutical composition comprising an effective amount of the compound of claim 2 ; and a pharmaceutical acceptable carrier.

Assignments (2)
SECURITY INTEREST Recorded Oct 18, 2023
From: CYDEX PHARMACEUTICALS, INC.; LIGAND PHARMACEUTICALS INCORPORATED; METABASIS THERAPEUTICS, INC.; PFENEX INC.
To: CITIBANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 065271/0025 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2021
From: ZHI, LIN
To: LIGAND PHARMACEUTICALS INCORPORATED
Reel/Frame 057121/0416 →
Cited By (1)
US 12,319,651