Fragment synthesis of substituted cyclic peptides
There is described herein use of a compound of formula (I) below to make cyclic peptides.
1. A cyclic peptide of formula (II):
or a stereoisomer thereof,
wherein:
—C(O)-L-Z— is selected from the group consisting of:
2. The cyclic peptide of claim 1 , or a stereoisomer thereof, wherein —C(O)-L-Z— is:
3. The cyclic peptide of claim 2 , or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is:
4. The cyclic peptide of claim 1 , or a stereoisomer thereof, wherein —C(O)-L-Z— is:
5. The cyclic peptide of claim 4 , or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is selected from the group consisting of:
6. The cyclic peptide of claim 1 , or a stereoisomer thereof, wherein —C(O)-L-Z— is:
7. The cyclic peptide of claim 6 , or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is:
8. The cyclic peptide of claim 1 , or a stereoisomer thereof, wherein —C(O)-L-Z— is:
9. The cyclic peptide of claim 8 , or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is:
10. The cyclic peptide of claim 1 , or a stereoisomer thereof, wherein —C(O)-L-Z— is:
11. The cyclic peptide of claim 10 , or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is:
12. A cyclic peptide, or a stereoisomer thereof, wherein the cyclic peptide, or stereoisomer thereof, is selected from the group consisting of: