IP Library Granted Patent US 11,458,110
Granted Patent B2
US 11,458,110 · App. 16/986,622 · Granted Oct 4, 2022

Treatment of Fragile X Syndrome with cannabidiol

Inventors: Marcel Bonn-Miller (Lexington, NC); Nancy Tich (Saint Paul, MN); Donna Gutterman (Raleigh, NC); John Messenheimer (Moncure, NC); Terri Sebree (Gladwyne, PA)
Assignee: ZYNERBA PHARMACEUTICALS, INC.
A61K31/05A61K9/0014A61K9/06A61K36/185A61P25/00
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Quick Facts
Patent No.
US 11,458,110
App. No.
16/986,622
Granted
Oct 4, 2022
Kind
B2
Abstract

The present technology relates to a method of treating one or more behavioral symptoms of Fragile X Syndrome in a subject by transdermally administering an effective amount of cannabidiol (CBD) to the subject wherein one or more behavioral symptoms of Fragile X Syndrome are treated in the subject.

Claims (7)

1. A method of treating a human suffering from Fragile X Syndrome comprising administering a therapeutically effective amount of isolated cannabidiol to the human suffering from Fragile X Syndrome to effectively treat the Fragile X Syndrome in the human in need thereof.

2. The method of claim 1 , wherein the therapeutically effective amount of isolated cannabidiol is between about 50 mg to 500 mg total daily.

3. The method of claim 2 , wherein the therapeutically effective amount of isolated cannabidiol is 250 mg total daily.

4. The method of claim 2 , wherein the therapeutically effective amount of isolated cannabidiol is 500 mg total daily.

5. The method of any of claim 3 and claim 4 , wherein the isolated cannabidiol is administered in two daily doses.

6. The method of claim 5 , wherein the isolated cannabidiol is (−)-cannabidiol.

7. The method of claim 1 , wherein the isolated cannabidiol is administered transdermally, and is formulated as a permeation-enhanced gel.

Assignments (2)
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded May 18, 2026
From: HARMONY BIOSCIENCES MANAGEMENT, INC. (F/K/A ZYNERBA PHARMACEUTICALS, INC.)
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 075642/0639 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 21, 2020
From: BONN-MILLER, MARCEL; TICH, NANCY; GUTTERMAN, DONNA; MESSENHEIMER, JOHN; SEBREE, TERRI
To: ZYNERBA PHARMACEUTICALS, INC.
Reel/Frame 054129/0816 →
Cited By (1)
US 12,582,664